The Role of Pericytes in Lipopolysaccharide-Induced Murine Acute Respiratory Distress Syndrome.

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome that is most commonly triggered by infection-related inflammation. Lung pericytes can respond to infection and act as immune and proangiogenic cells; moreover, these cells can differentiate into myofibroblasts in nonresolving ARDS and contribute to the development of pulmonary fibrosis. Here, we aimed to characterize the role of lung cells, which present characteristics of pericytes, such as peri-endothelial location and expression of a panel of specific markers.

All-fiber tunable devices based on high-index photonic crystal fibers filled with liquid crystals.

In this paper we present all-in fiber tunable devices based on specially designed and optimized high-index photonic crystal fibers filled with nematic liquid crystals. A special host microstructured optical fibers have been designed and manufactured to ensure low-loss index guiding and mode field diameter matching to SMF-28 fiber, ensuring low losses on interconnections with leading in-out FC/PC connectorized pigtails. We present four types of tunable all-fiber devices: tunable retarders with tuning range as high as 20 λ, tunable polarizers with variable axis of polarization and continuously tunable polarization dependent losses, tunable and fully controllable polarization controller and finally indeterministic depolarizer in which depolarization is caused by random thermodynamic process.

Periodic liquid crystalline waveguiding microstructures.

Different methods allowing for creating optical waveguides with liquid-crystal (LC) cores, in which molecules form periodic patterns with precisely controlled periods, are reported. The first one is based on reversible photoalignment with high-resolution selective illumination and allows to control the period of LC molecules inside silica microcapillaries. The second method employs microstructures formed in PDMS, allowing to obtain both: LC-core waveguides and a set of specially designed periodic microelectrodes used for the periodic reorientation of molecules.

How I see is how I feel. Identification of illness perception schema and its association with adaptation outcomes in multiple sclerosis - a 5-year prospective study.

The aim of the study was to assess the role of illness perception in adaptation to chronic disease among patients with relapsing-remitting multiple sclerosis (RRMS). The differences between the obtained configurations of the illness perception components during four measurements and the model of predictions of the values of adaptation indicators, i.e.

Spring Model - Chromatin Modeling Tool Based on OpenMM.

Chromatin structure modeling is a rapidly developing field. Parallel to the enormous growth of available experimental data, there is a growing need of building and visualizing 3D structures of nuclei, chromosomes, chromatin domains, and single loops associated with particular gene loci. Here, we present a tool for chromatin domain modeling; it is available as a webservice and standalone python script.