Publications by authors named "J Rouault"
Article Synopsis
- * Researchers found that knocking out BTG1 increases the severity of the disease, especially when paired with Bcl2 overexpression.
- * Additionally, they identified a partnership between BTG1 and the protein BCAR1, leading to enhanced cell migration when BTG1 is mutated or deleted, which can potentially be treated with SRC inhibitors like dasatinib.
Article Synopsis
- - Peripheral T cell lymphomas (PTCLs) have poor clinical outcomes and are linked to chronic T cell receptor (TCR) activation, but their exact mechanisms are not well understood.
- - Research using a mouse model shows that while chronic TCR stimulation can lead to the development of PTCLs, it does not help their survival; instead, PTCLs reprogram to adopt characteristics similar to natural killer (NK) cells, expressing NK cell receptors (NKRs) and relying on specific signaling pathways.
- - Analysis of human PTCL cases indicates that a similar reprogramming occurs, prompting the need for clinical studies targeting molecules like SYK and NKRs to potentially improve treatment outcomes for this aggressive cancer.
Background: Although transposons have been identified in almost all organisms, genome-wide information on mariner elements in Aphididae remains unknown. Genomes of Acyrthosiphon pisum, Diuraphis noxia and Myzus persicae belonging to the Macrosiphini tribe, actually available in databases, have been investigated.
Results: A total of 22 lineages were identified.
Adult neurogenesis occurs throughout life in the dentate gyrus (DG) and the subventricular zone (SVZ), where glia-like stem cells generate new neurons. Voluntary running is a powerful neurogenic stimulus triggering the proliferation of progenitor cells in the DG but, apparently, not in the SVZ. The antiproliferative gene Btg1 maintains the quiescence of DG and SVZ stem cells.
View Article and Find Full Text PDFThe piggyBac transposable element was originally isolated from the cabbage looper moth, Trichoplusia ni, in the 1980s. Despite its early discovery and specificity compared to the other Class II elements, the diversity and evolution of this superfamily have been only partially analyzed. Two main types of elements can be distinguished: the piggyBac-like elements (PBLE) with terminal inverted repeats, untranslated region, and an open reading frame encoding a transposase, and the piggyBac-derived sequences (PGBD), containing a sequence derived from a piggyBac transposase, and which correspond to domesticated elements.
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