Publications by authors named "J Rotmans"
Hemodynamic considerations in arteriovenous vascular access modalities for hemodialysis.
J Cardiovasc Surg (Torino)
November 2024
Article Synopsis
- * These disturbances can cause complications such as endothelial dysfunction and vascular stenosis, leading to low patency rates and potential cardiac issues.
- * The review discusses various techniques and modifications, including surgical methods and graft designs, aimed at correcting hemodynamic problems to improve long-term patient outcomes.
Article Synopsis
- BK polyomavirus-associated nephropathy (BKPyVAN) is a significant complication after kidney transplantation, usually managed by reducing immunosuppression when BK polyomavirus (BKPyV) is detected.
- A study involving 1,076 kidney transplant recipients found a higher risk of developing de novo donor-specific antibodies (dnDSA) in patients with high BKPyV DNA loads compared to those without, suggesting that the required immunosuppression reduction can worsen immune responses.
- While high BKPyV DNAemia increased dnDSA risk, there was no significant difference in the occurrence of biopsy-proven acute rejection (BPAR) between groups, indicating a need for better strategies to manage BKPyV infections in transplant patients.
Genetic testing in a national cohort of adults with chronic kidney disease of unknown origin.
Nephrol Dial Transplant
November 2024
Article Synopsis
- Chronic kidney disease (CKD) is unexplained in 20% of patients, and this study investigates the use of massively parallel sequencing (MPS) as a diagnostic tool for these cases.
- The study found that in 340 participants, a genetic diagnosis was identified in 17% of cases, leading to clinical consequences in 73% of those diagnosed.
- Barriers to implementation of genetic testing included genetic illiteracy among nephrologists, difficulties in test selection, and lack of time, highlighting the need for better education in genetics.
5/6 Nephrectomy impairs acute kaliuretic responses and predisposes to postprandial hyperkalemia.
Am J Physiol Renal Physiol
December 2024
The susceptibility of patients with chronic kidney disease to develop postprandial hyperkalemia suggests alterations in normal kidney sodium (Na) and potassium (K) handling, but the exact nature of these changes is largely unknown. To address this, we analyzed the natriuretic and kaliuretic responses to diuretics and acute K loading in rats who underwent 5/6 nephrectomy (5/6Nx) and compared this with the response in sham-operated rats. The natriuretic and kaliuretic responses to furosemide, hydrochlorothiazide, and amiloride were largely similar between 5/6Nx and sham rats except for a significantly reduced kaliuretic response to hydrochlorothiazide in 5/6Nx rats.
View Article and Find Full Text PDFNutcracker syndrome (a Delphi consensus).
J Vasc Surg Venous Lymphat Disord
January 2025
Background: Nutcracker syndrome (NCS) describes the symptomatic compression of the left renal vein between the aorta and superior mesenteric artery. Whereas asymptomatic compression is a common radiological finding, patients with NCS can report a range of symptoms. There are no specific diagnostic criteria and interventions include a range of open surgical and endovascular procedures.
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