Clinical Manifestations.

Background: Anti-amyloid beta (Aβ) immunotherapies have recently evolved as promising treatment options in patients with early symptomatic Alzheimer's disease (AD). Meanwhile, accurate patient selection for these treatments might be challenging mirrored by strict selection criteria of the hitherto published clinical trials. Based on a real-world tertiary care sample of post-mortem validated cases, we aimed to identify the patients matching these selection criteria and their proportion showing post-mortem AD pathology.

Randomized clinical trial protocol of an app-based intervention to prevent postpartum depression.

Purpose: To develop and evaluate the effectiveness of an asynchronously delivered app, InBloom, for postpartum depression (PPD) prevention relative to an evidence-based synchronously delivered in-person intervention, ROSE (Reach Out, Stay Strong, Essentials for mothers of newborns) for depression and return on investment via a prospective randomized controlled trial and quasi-experimental cohort analyses.

Background: PPD affects 1 in 7 gestational parents in the US, causing emotional distress, consequences for infant development and child adjustment, disruptions in family relationships, and financial burden. ROSE is an evidence-based intervention administered as four in-person group sessions plus one postpartum booster session.

Computational exploration of M-sites with chemical order and disorder in M'M''B and M'M''B compounds.

Boron-based materials are highly desirable for their promising mechanical properties, rendering them ideal for various industrial applications. In this study, we take advantage of the two unique metal Wyckoff sites in the prototype structures VB (4 and 2) and CrB (16 and 4). These two sites were populated by two different metals, M' and M'', forming novel B-based ternary M'M''B and M'M''B compounds.

A 36-Year-Old Patient With Crohn Disease and Bilateral Pleural Effusions.

A 36-year-old man with severe Crohn disease complicated by urethral strictures and enterocutaneous and enterovesicular fistulas presented for several weeks of poor appetite, weight loss, failure to thrive, and newly worsening altered mentation. Further history revealed he chronically did not urinate through his urethra, but rather "leaked" through multiple enterocutaneous fistulas in his abdomen and perineum. Medications included ustekinumab (anti-IL12/IL23 monoclonal antibody) for Crohn disease, methadone, and hydrocodone.

Mechanistical Study on Substrate-Controlled Highly Selective [2+2] and [2+3] Cycloaddition Reactions.

Polycyclic conjugated hydrocarbons have acquired increased interests recently because of their potential applications in electronic devices. On metal surfaces, the selective synthesis of four- and five-membered carbon rings remains challenging due to the presence of diverse reaction pathways. Here, utilizing the same precursor molecule, we successfully achieved substrate-controlled highly selective cycloaddition reactions towards four- and five-membered carbon rings.