Publications by authors named "J Rosch"
Bacterial cells secrete extracellular vesicles (EVs), the function of which is a matter of intense investigation. Here, we show that the EVs secreted by the human pathogen (pneumococcus) are associated with bacterial DNA on their surface and can deliver this DNA to the transformation machinery of competent cells. These findings suggest that EVs contribute to gene transfer in Gram-positive bacteria and, in doing so, may promote the spread of drug resistance genes in the population.
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- Virulence studies on the one-carbon metabolism pathway and proline synthesis indicate their importance in the infection process, particularly in Δ and Δ mutant strains of capsular serotype 6B BHN418.* -
- These mutant strains showed significantly reduced virulence in models of mouse sepsis and pneumonia despite being able to colonize the nasopharynx and grow normally in nutrient-rich environments.* -
- Differences in metabolic profiles and gene transcription under various stress conditions revealed strain-specific effects on virulence and metabolism, underscoring the need for rapid adaptation to host physiological conditions.*
Article Synopsis
- Scientists found that a bacteria called Streptococcus pneumoniae uses different systems to talk to itself!
- Two important parts of the bacteria, PptAB and Eep, help connect these communication systems and control how they work together when the bacteria infect a host!
- This discovery shows that many types of bacteria could use a similar way to communicate, making it an important finding for understanding germs!
Purpose: Traffic accidents persist as a leading cause of death. European law mandates the integration of automatic emergency call systems (eCall). Our project focuses on an automated injury prediction device for car accidents, correlating technical and epidemiological input data, such as age, gender, seating position, impact on the passenger compartment, seatbelt usage, impact direction, EES, vehicle class, and airbag deployment.
View Article and Find Full Text PDFCommensal gut bacteria use oleate hydratase to release a spectrum of hydroxylated fatty acids using host-derived unsaturated fatty acids. These compounds are thought to attenuate the immune response, but the underlying signaling mechanism(s) remain to be established. The pathogen also expresses an oleate hydratase and 10-hydroxyoctadecanoic acid (18:0) is the most abundant oleate hydratase metabolite found at Staphylococcal skin infection sites.
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