Cell-derived Newcastle disease virus variant with two amino acid substitutions near cleavage site of F shows favorable traits as oncolytic virus.

Newcastle disease virus (NDV) has shown encouraging effectiveness in , , and in early clinical trials as a viro-immunotherapy for pancreatic cancer. Previously, NDV used in clinical trials was produced in embryonated chicken eggs; however, egg-produced viruses are known to be partly neutralized by the human complement system when administered intravenously. Here, an NDV variant (NDV F0) was generated for production in mammalian cells, without passage in eggs.

The missing link: How is the phantom limb influenced by prosthesis wearing in people with lower-limb amputation?

Background: Recent therapeutic and technological solutions aim to improve the daily living of people with limb amputation by considering various aspects of the phantom limb, in particular painless phantom sensations (PS) and voluntary phantom movements (VPM).

Objective: Although previous research has explored these phenomena mostly without considering the prosthesis, this study investigates the influence of prosthesis wearing on painless PS, painful PS, and VPM, in people with lower-limb amputation.

Study Design: Cross-sectional study based on semi-directed interviews.

Let this be a safe place: a qualitative study into midwifery care for forcibly displaced women in the Netherlands.

Background: Forcibly displaced women in the Netherlands face increased chances of perinatal mortality and other adverse pregnancy and childbirth outcomes compared to the resident country population, which has been linked to suboptimal care. This study was conducted to gain insights from the experiences of Dutch midwives to inform and enhance the provision of tailored and equitable care for forcibly displaced women.

Methods: We conducted a qualitative study using semistructured interviews with community midwives who provide care for forcibly displaced women (asylum seekers and recognized refugees) in the Netherlands.

Fivefold increased power handling in waveguide UTC-PDs using dual-injection shared CPW PD-arrays.

This work presents two circuit-based solutions to enhance the power handling capabilities of waveguide-integrated uni-travelling carrier photodetectors (WG-UTC-PDs). Compared to a baseline WG-UTC-PD, these solutions achieve a fivefold increase in photocurrent before thermal breakdown. First, dual-injection improves the optical power distribution within a baseline WG-UTC-PD, raising the photocurrent threshold before thermal breakdown.

Evaluation of participation in a former rehabilitation population: a comparison between USER-Participation Restriction and Satisfaction subscales and PROMIS Ability to Participate and PROMIS Satisfaction with participation 8-item short forms in a cross-sectional multicentre study.

Background: Several Patient Reported Outcome Measurements (PROMs) can be used to quantify participation in rehabilitation patients, yet there is limited comparative research on their content and psychometric properties to make an informed decision between them.

Objective: To compare the content and several psychometric properties of the Restriction and Satisfaction subscales of the Utrecht Scale for Evaluation of Rehabilitation - Participation (USER-P) with the Patient-Reported Outcomes Measurement Information System Ability to Participate in Social Roles and Activities (PROMIS-APS) and Satisfaction with Social Roles and Activities (PROMIS-SPS) v2.0 8-item short forms.