Publications by authors named "J Rolo"
Objectives: Despite being a commensal of human skin, Cutibacterium acnes plays an important role in the pathogenesis of Acne vulgaris, with the loss of bacterial phylotype diversity being related to disease progression. This study evaluated differences in the virulence profile of C. acnes strains from different phylotypes and investigated the possible phylotype-selective efficacy of essential oils (EOs) from Thymus x citriodorus (TC), Thymus mastichina, and Cistus ladanifer compared to Melaleuca alternifolia (tea tree), focusing on both planktonic and biofilm growth forms, the latter being related with pathogenesis and treatment resistance.
View Article and Find Full Text PDFHuman papillomavirus (HPV)-associated cervical cancer is the most common cancer among women worldwide. The treatment options are strongly related to increased infertility in women. Imiquimod (IQ) is an imidazoquinoline, which has proven antiviral effects against persistent HPV infection by activating immune cells via Toll-like receptors 7/8 when formulated in carriers, like nanogels, for topical use.
View Article and Find Full Text PDFUnlabelled: Humulus lupulus extracts have in their composition different molecules, such as polyphenols, α-acids, β-acids, and hydrocarbons, which contribute to the plant's medicinal properties. These molecules are associated with antimicrobial, antioxidant and anti-inflammatory activities.
Objective: This work focuses on the evaluation of H.
Article Synopsis
- The study investigates the role of the vaginal fungal community, known as mycobiota, in health, using advances in sequencing technologies to identify fungi associated with vulvovaginal infections.
- The primary focus was on the interaction between the opportunistic pathogenic fungus spp. and other yeast species, analyzing their growth, biofilm formation, and pathogenic potential in co-culture experiments.
- Results indicated a symbiotic relationship between spp. and spp., which enhanced growth and biofilm formation, while other yeast species displayed antagonistic interactions, potentially reducing pathogenicity and highlighting the complexity of vaginal mycobiome interactions.
Article Synopsis
- - Severe asthma affects roughly 10% of asthma patients and is marked by poor lung function and high eosinophil counts; this study aims to define asthma remission more clearly using a structured method.
- - A panel of experts developed and refined a questionnaire through a two-round Delphi method to evaluate consensus on criteria for asthma remission, including clinical and inflammatory aspects.
- - The analysis confirmed specific criteria for both complete and partial clinical remission, creating a practical tool to assess treatment effectiveness in patients with severe asthma enrolled in the Severe Asthma Network Italy registry.