Publications by authors named "J Rojas-Quintero"
Article Synopsis
- Researchers observed that mice lacking a protein called CLEC2, which affects lymphatic function, develop lung issues similar to emphysema in COPD due to the formation of tertiary lymphoid organs (TLOs).
- Blocking the formation of these TLOs with an anti-CD20 antibody in these mice partially prevented the progression of emphysema and revealed that TLOs contributed to increased autoantibodies.
- The study also found that chronic exposure to cigarette smoke enlarged TLOs and was linked to more severe lung injury, and similar lymphatic changes were noted in lung tissues from COPD patients with emphysema, suggesting a connection between lymphatic dysfunction and autoimmune responses in lung disease.
Viral myocarditis, an inflammatory disease of the heart, causes significant morbidity and mortality. Type I interferon (IFN)-mediated antiviral responses protect against myocarditis, but the mechanisms are poorly understood. We previously identified A Disintegrin And Metalloproteinase domain 9 (ADAM9) as an important factor in viral pathogenesis.
View Article and Find Full Text PDFChimeric antigen receptor T cell (CAR T cell) therapy has emerged as a prominent adoptive cell therapy and a therapeutic approach of great interest in the fight against cancer. This approach has shown notorious efficacy in refractory hematological neoplasm, which has bolstered its exploration in the field of solid cancers. However, successfully managing solid tumors presents considerable intrinsic challenges, which include the necessity of guiding the modified cells toward the tumoral region, assuring their penetration and survival in adverse microenvironments, and addressing the complexity of identifying the specific antigens for each type of cancer.
View Article and Find Full Text PDFChronic obstructive pulmonary disease (COPD) is a heterogeneous condition. We hypothesized that the unbiased integration of different COPD lung omics using a novel multilayer approach might unravel mechanisms associated with clinical characteristics. We profiled mRNA, microRNA and methylome in lung tissue samples from 135 former smokers with COPD.
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