Developing new drugs for adult T-cell leukemia/lymphoma by targeting hypoxia: insights from toxicity of MS-275 and its analogs.

The low survival rate of adult T-cell leukemia/lymphoma (ATL) underscores the critical need for innovative therapeutic agents. While the pharmacokinetics of HDACis have been documented in several hematological neoplasms, there is a notable gap in research regarding their activity against ATL. Given that hypoxia can induce unpredictable effects on lymphoma cells, this study aimed to evaluate the toxic effects of MS-275 and novel analogs on ATL cells in hypoxic condition for the first time.

The impact of work rest scheduling for prolonged standing activity.

Prolonged standing can cause discomfort on the body of the workers and can lead to injury and occupational disease. One of the ergonomic intervention is through improving the work-rest scheduling. The purpose of this study are to identify the fatigue level from the perception of the worker and to investigate the impact of the work-rest scheduling to the standing workers for 12 h working time with a different gender.

Complete immunization coverage and its determinants among children in Malaysia: findings from the National Health and Morbidity Survey (NHMS) 2016.

Objectives: The success of the Expanded Program on Immunization among children will greatly reduce the burden of illness and disability from vaccine preventable diseases. The aim of the study was to evaluate the complete immunization coverage and its determinants among children aged 12-23 months in Malaysia.

Study Design: Cross-sectional study.

Backpack-back pain complexity and the need for multifactorial safe weight recommendation.

The study analysed backpack-related back pain in school children by investigating the possibility of multiple interactions among causative factors, which may be responsible for the non-conclusive findings on the issue. Using data from 444 prepubescent schoolchildren, a mixed method design combining survey, observation and direct measurement strategies was implemented. Using a multivariate structural equation modelling approach, the study investigated interactions among anthropometry, posture, backpack volume, rating and back pain constructs, with each construct made of 2-4 indicators.

Interaction of body mass index and age in muscular activities among backpack carrying male schoolchildren.

Background: The complex and limited understanding of the interactions among multiple factors associated with back pain occurrence among schoolchildren might explain the current inconclusive and contradictory findings on the issue. The global increase in the prevalence of childhood overweight and obesity, which reportedly affects children's physical abilities, calls for concern among school/children ergonomists and other stakeholders.

Objective: The study investigated the interaction of body mass index (BMI) and age on the muscular activities, backpack height and perceived level of pain arising from carrying different weight of backpacks.