Publications by authors named "J Rogozik"
Challenges in the management of familial hypercholesterolemia: a case report.
Front Cardiovasc Med
September 2024
Article Synopsis
- - Familial hypercholesterolemia (FH) is a genetic disorder causing high LDL cholesterol levels, which increases the risk of heart disease; the heterozygous form affects about 1 in 500 people worldwide.
- - A case study reported a woman with HeFH whose LDL levels did not adequately decrease with statin and ezetimibe therapies; genetic testing revealed a mutation in the LDL receptor gene.
- - Inclisiran therapy, which uses a specialized RNA to lower LDL cholesterol, significantly reduced her cholesterol levels after three months and may be a viable option for patients who cannot tolerate traditional treatments.
Article Synopsis
- Familial hypercholesterolemia (FH) is a genetic disorder that causes high LDL cholesterol levels, increasing the risk of early cardiovascular diseases due to atherosclerosis.
- A study involving 17 patients treated between 2019 and 2024 found the most common genetic mutation affecting LDL levels, with significant responses to alirocumab treatment among those with single mutations.
- Patients with double mutations showed much less effectiveness in reducing LDL cholesterol, highlighting a need for different treatment strategies for those cases.
Lipid disorders play a critical role in the intricate development of atherosclerosis and its clinical consequences, such as coronary heart disease and stroke. These disorders are responsible for a significant number of deaths in many adult populations worldwide. Familial hypercholesterolemia (FH) is a genetic disorder that causes extremely high levels of LDL cholesterol.
View Article and Find Full Text PDF2 pi affinity level of adsorbed CO: Bonding and dispersion.
Phys Rev B Condens Matter
September 1985