Publications by authors named "J Rodriguez-Santiago"
The aim of this study was to evaluate different preoperative immune, inflammatory, and nutritional scores and their best cut-off values as predictors of poorer overall survival (OS) and disease-free survival (DFS) in patients who underwent curative gastric cancer resection. This was a retrospective observational multicentre study based on data of the Spanish EURECCA Esophagogastric Cancer Registry. Time-dependent Youden index and log-rank test were used to obtain the best cut-offs of 18 preoperative biomarkers for OS and DFS.
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- A comprehensive analysis of 356 Klebsiella pneumoniae species complex isolates revealed three main types: classical (cl), presumptive hypervirulent (p-hv), and hypermucoviscous-like (hmv-like), with the majority being classical at 82.3%.
- Most classical isolates produced extended-spectrum-β-lactamases (ESBLs), and a small percentage showed colistin resistance, while all p-hv strains were antibiotic-susceptible.
- The study found significant differences in capsule production between the different types, which affected virulence, and highlighted the emergence of atypical hypervirulent strains in the population, emphasizing the importance of tracking these pathogens in Mexican healthcare settings.
In this study, we report the carbapenemase-encoding genes and colistin resistance in , , , and in the second year of the COVID-19 pandemic. Clinical isolates included carbapenem-resistant , carbapenem-resistant , carbapenem-resistant , and carbapenem-resistant . Carbapenemase-encoding genes were detected by PCR.
View Article and Find Full Text PDFObjective: To develop and validate a risk prediction model of 90-day mortality (90DM) using machine learning in a large multicenter cohort of patients undergoing gastric cancer resection with curative intent.
Background: The 90DM rate after gastrectomy for cancer is a quality of care indicator in surgical oncology. There is a lack of well-validated instruments for personalized prognosis of gastric cancer.
Article Synopsis
- The study investigates how using colistin in livestock, particularly in piglets, contributes to the rise of colistin-resistant bacteria.
- The researchers collected 175 colonies from pig feces and identified colistin resistance using various tests, finding that resistance was linked to specific plasmid-borne genes.
- Whole-genome sequencing revealed a diverse range of resistance and virulence genes, indicating that colistin resistance may develop through different acquisition pathways, presenting a risk for human health due to the potential spread of these resistant strains.