Development and validation of a molecular classifier of meningiomas.

Background: Meningiomas exhibit considerable clinical and biological heterogeneity. We previously identified four distinct molecular groups (immunogenic, NF2-wildtype, hypermetabolic, proliferative) that address much of this heterogeneity. Despite the utility of these groups, the stochasticity of clustering methods and the use of multi-omics data for discovery limits the potential for classifying prospective cases.

The importance of a vice chair in a department of surgery: A chair's perspective.

From the perspective of chair, there is essential work to do before designating a vice chair, leader, and/or advocate for departmental inclusivity, and that is to work to create a departmental culture that values diversity, embraces different worldviews, and includes a variety of different perspectives. It is important to empower and resource with protected time and budget a vice chair who can be active and intentional day in and day out to create, maintain (and hopefully expand) an inclusive community. Their work should be augmented with a committee inclusive of staff, faculty, and trainees who can provide feedback and creative ideas.

Comparative analysis of the LARP1 C-terminal DM15 region through Coelomate evolution.

TOR (target of rapamycin), a ubiquitous protein kinase central to cellular homeostasis maintenance, fundamentally regulates ribosome biogenesis in part by its target La-related protein 1 (LARP1). Among other target transcripts, LARP1 specifically binds TOP (terminal oligopyrimidine) mRNAs encoding all 80 ribosomal proteins in a TOR-dependent manner through its C-terminal region containing the DM15 module. Though the functional implications of the LARP1 interaction with target mRNAs is controversial, it is clear that the TOP-LARP1-TOR axis is critical to cellular health in humans.