Entropy Production in an Electro-Membrane Process at Underlimiting Currents-Influence of Temperature.

The entropy production in the polarization phenomena occurring in the underlimiting regime, when an electric current circulates through a single cation-exchange membrane system, has been investigated in the 3-40 °C temperature range. From the analysis of the current-voltage curves and considering the electro-membrane system as a unidimensional heterogeneous system, the total entropy generation in the system has been estimated from the contribution of each part of the system. Classical polarization theory and the irreversible thermodynamics approach have been used to determine the total electric potential drop and the entropy generation, respectively, associated with the different transport mechanisms in each part of the system.

Equilibrium, transient dynamics and sustainable reference points under age-specific natural mortality rates and varying levels of population productivity: The case of the Northern cod stock.

Scientific advisory bodies provide scientific advice for sustainable fisheries management based on the precautionary approach and maximum sustainable yield (MSY) reference points, such as spawning stock biomass (SSB) value B, and fishing mortality giving MSY, F. The lack of a stock-recruitment function (SRF) to identify a clear breakpoint B has recently emerged in important stock collapses. It also precludes the use of equilibrium-based methods to analyze the sustainability of F.

A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer.

Background: This multicentre, open-label, Phase Ib/II trial evaluated the insulin-like growth factor (IGF) 1/2 neutralising antibody xentuzumab plus enzalutamide in metastatic castrate-resistant prostate cancer (mCRPC).

Methods: The trial included Phase Ib escalation and expansion parts and a randomised Phase II part versus enzalutamide alone. Primary endpoints in the Phase Ib escalation, Phase Ib expansion and Phase II parts were maximum tolerated dose (MTD), prostate-specific antigen response and investigator-assessed progression-free survival (PFS), respectively.

Clinical implications of changing thyroglobulin and antithyroglobulin antibodies analytical methods in the follow-up of patients with differentiated thyroid carcinoma.

Background And Aims: Patients' response to treatment in differentiated thyroid cancer (DTC) is classified according to serum thyroglobulin concentrations (Tg), usually using the American Thyroid Association guidelines and considering potential interfering anti-thyroglobulin antibodies (Ab-Tg). We aim to evaluate the clinical implications of changing Tg and Ab-Tg quantification method.

Material And Methods: Tg and Ab-Tg were quantified in 82 serum samples (60 from DTC patients) by Elecsys and Access immunoassays.

Reassessment of the human mandible from Banyoles (Girona, Spain).

Since the discovery of a human mandible in 1887 near the present-day city of Banyoles, northeastern Spain, researchers have generally emphasized its archaic features, including the lack of chin structures, and suggested affinities with the Neandertals or European Middle Pleistocene (Chibanian) specimens. Uranium-series and electron spin resonance dating suggest the mandible dates to the Late Pleistocene (Tarantian), approximately ca. 45-66 ka.