Publications by authors named "J Rodrigues Loureiro"
The major histocompatibility complex (MHC) class I-related molecule MHC-class-I-related protein 1 (MR1) presents metabolites to distinct MR1-restricted T cell subsets, including mucosal-associated invariant T (MAIT) and MR1T cells. However, self-reactive MR1T cells and the nature of recognized antigens remain underexplored. Here, we report a cell endogenous carbonyl adduct of adenine (8-(9H-purin-6-yl)-2-oxa-8-azabicyclo[3.
View Article and Find Full Text PDFVertebrates' tongues reflect part of their adaptations to diverse feeding strategies, the types of food items they eat, and the environments where they live. Our contribution was to analyze the macro- and microscopic morphology of the tongues of two porpoise species ( and ; juveniles and adults), whose biology is little known. Macroscopic and microscopic studies (conventional histology, scanning electron microscopy, immunohistochemistry, and morphometry) were performed.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on creating new drug analogues of 1,25-dihydroxyvitamin D3 by incorporating silicon bioisosteres to enhance their therapeutic effects.
- - Six silicon-containing analogues were designed and synthesized using a specific chemical method, revealing unique crystal structures that stabilize the VDR's active form.
- - These analogues exhibit comparable binding and activity to the natural hormone but cause less increase in calcium levels, and when paired with chemotherapy, they effectively reduce cell growth.