Publications by authors named "J Rodney Folz"
Article Synopsis
- Tc toxins are harmful proteins from bacteria that can pierce cell membranes, allowing them to introduce toxic enzymes into cells.
- Their transition from an inactive to an active state has been studied, revealing it takes about 30 hours and involves multiple steps and intermediates.
- Factors like higher pH and the presence of certain receptors speed up this process, with the actual ejection of the channel happening in under 60 milliseconds, highlighting potential uses for these toxins in medicine and pest control.
While alterations in both physiological responses to others' emotions as well as interoceptive abilities have been identified in autism, their relevance in altered emotion recognition is largely unknown. We here examined the role of interoceptive ability, facial mimicry, and autistic traits in facial emotion processing in non-autistic individuals. In an online Experiment 1, participants (N = 99) performed a facial emotion recognition task, including ratings of perceived emotional intensity and confidence in emotion recognition, and reported on trait interoceptive accuracy, interoceptive sensibility and autistic traits.
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- Acrolein is a toxic environmental compound that is also produced by gut microbes, but it quickly dissipates from cell culture media, complicating research on its effects.
- A new biosynthesis system was developed using spermine and calf serum to continuously produce acrolein, while managing hydrogen peroxide byproducts, allowing for better study of acrolein's impact on human cells.
- Experiments showed that human colon cells responded similarly to the biosynthetically produced acrolein and pure acrolein regarding gene expression related to oxidative stress and DNA damage, paving the way for more accurate studies on acrolein exposure.
Photoacoustic lifetime oxygen imaging of radiotherapy-induced tumor reoxygenation .
J Photochem Photobiol
June 2024
Purpose: Early detection and diagnosis of cancer is critical for achieving positive therapeutic outcomes. Biomarkers that can provide clinicians with clues to the outcome of a given therapeutic course are highly desired. Oxygen is a small molecule that is nearly universally present in biological tissues and plays a critical role in the effectiveness of radiotherapies by reacting with DNA radicals and subsequently impairing cellular repair of double strand breaks.
View Article and Find Full Text PDFTyrosine sulfation, an understudied but crucial post-translational modification, cannot be directly detected in conventional nanoflow liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) due to the extreme sulfate lability. Here, we report the detection of sulfate-retaining fragments from LC-electron capture dissociation (ECD) and nanoLC-electron transfer higher energy collision dissociation (EThcD). Sulfopeptide candidates were identified by Proteome Discoverer and MSFragger analysis of nanoLC-HCD MS/MS data and added to inclusion lists for LC-ECD or nanoLC-EThcD MS/MS.
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