Nanodots of Transition Metal Sulfides, Carbonates, and Oxides Obtained Through Spontaneous Co-Precipitation with Silica.

The controlled formation and stabilization of nanoparticles is of fundamental relevance for materials science and key to many modern technologies. Common synthetic strategies to arrest growth at small sizes and prevent undesired particle agglomeration often rely on the use of organic additives and require non-aqueous media and/or high temperatures, all of which appear critical with respect to production costs, safety, and sustainability. In the present work, we demonstrate a simple one-pot process in water under ambient conditions that can produce particles of various transition metal carbonates and sulfides with sizes of only a few nanometers embedded in a silica shell, similar to particles derived from more elaborate synthesis routes, like the sol-gel process.

Lifestyle Behaviors of Bronx Middle-School Students Enrolled in an Afterschool Program: Lessons Learned from the COVID-19 Shutdown.

A minority of American youth meet CDC lifestyle behavior recommendations. Children in the Bronx face barriers to healthy behaviors amplified by COVID-19. This research evaluated baseline behavior among distinct cohorts attending afterschool programming before and after the COVID-19 shutdown.

Targeting c-MET for Endoscopic Detection of Dysplastic Lesions within Barrett's Esophagus Using EMI-137 Fluorescence Imaging.

Purpose: Esophageal cancer carries a poor prognosis with a 5-year overall survival of less than 20%. Barrett's esophagus increases the risk of esophageal adenocarcinoma. The aim of this study was to investigate the ability of EMI-137, a mesenchymal-epithelial transition factor (c-MET)-targeting optical imaging tracer, to detect dysplasia in Barrett's esophagus.

PARP1-targeted fluorescence molecular endoscopy as novel tool for early detection of esophageal dysplasia and adenocarcinoma.

Background: Esophageal cancer is one of the 10 most common cancers worldwide and its incidence is dramatically increasing. Despite some improvements, the current surveillance protocol with white light endoscopy and random untargeted biopsies collection (Seattle protocol) fails to diagnose dysplastic and cancerous lesions in up to 50% of patients. Therefore, new endoscopic imaging technologies in combination with tumor-specific molecular probes are needed to improve early detection.