Publications by authors named "J Rico-Feijoo"
Synergistic impact of innate immunity hyper-activation and endothelial dysfunction on the magnitude of organ failure in the infection-sepsis continuum.
Int J Infect Dis
September 2024
Objectives: Identifying host response biomarkers implicated in the emergence of organ failure during infection is key to improving the early detection of this complication.
Methods: Twenty biomarkers of innate immunity, T-cell response, endothelial dysfunction, coagulation, and immunosuppression were profiled in 180 surgical patients with infections of diverse severity (IDS) and 53 with no infection (nIDS). Those better differentiating IDS/nIDS in the area under the curve were combined to test their association with the sequential organ failure assessment score by linear regression analysis in IDS.
Influence of lymphopenia on long-term mortality in septic shock, a retrospective observational study.
Rev Esp Anestesiol Reanim (Engl Ed)
May 2024
Background And Objective: The diagnosis of infection, to diagnose septic shock, has been qualified by leukocyte counts and protein biomarkers. Septic shock mortality is persistently high (20%-50%), and rising in the long term. The definition of sepsis does not include leukocyte count, and lymphopenia has been associated with its mortality in the short term.
View Article and Find Full Text PDFArticle Synopsis
- Low levels of anti-SARS-CoV-2 S antibodies in critically ill COVID-19 patients are linked to higher mortality rates and suggest that these antibodies play a protective role.
- The study involved 92 ICU patients and showed that absence of these antibodies coincided with increased viral RNA in plasma and higher rates of N-antigenaemia.
- The findings indicate that monitoring antibody levels could be crucial for understanding patient outcomes and managing severe COVID-19 cases effectively.
Background: COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus.
View Article and Find Full Text PDFPurpose: We hypothesized that neurally adjusted ventilatory assist (NAVA) compared to conventional lung-protective mechanical ventilation (MV) decreases duration of MV and mortality in patients with acute respiratory failure (ARF).
Methods: We carried out a multicenter, randomized, controlled trial in patients with ARF from several etiologies. Intubated patients ventilated for ≤ 5 days expected to require MV for ≥ 72 h and able to breathe spontaneously were eligible for enrollment.