Publications by authors named "J Richard Premkumar"
In this study, we unveil a novel method for the asymmetric dearomatization of indoles under cobalt/photoredox catalysis. By strategically activating C-H bonds of amides and subsequent migratory insertion of π-bonds present in indole as reactive partner, we achieve syn-selective tetrahydro-5H-indolo[2,3-c]isoquinolin-5-one derivatives with excellent yields and enantiomeric excesses of up to >99 %. The developed method operates without a metal oxidant, relying solely on oxygen as the oxidant and employing an organic dye as a photocatalyst under irradiation.
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- The text discusses a new metal-catalyzed method for creating complex P-chiral molecules using C-H bond annulation, which is efficient in terms of atom and step economy.
- Researchers utilized Co(II) salt and chiral Salox ligands to achieve regio-reversal and enantioselective reaction with phosphinamide and bromoalkyne, leading to high enantiomeric excess (>99%).
- The study outlines a mechanism involving ligand-assisted cyclocobaltation, regioselective insertion, and reductive elimination, supported by experimental evidence, including the isolation of a cobaltacycle.
Background: The World Health Organization's "End TB Strategy" aims to end global tuberculosis (TB) epidemic through a holistic combination of health and social interventions placing the patients and communities at the heart of the response. This study aimed to assess the effectiveness of utilizing school children as ambassadors in TB advocacy.
Materials And Methods: We adopted a quasi-experimental intervention design where students' awareness level was assessed before and after the intervention.
Technology advancement, industrialisation, and globalisation have been significant reasons for air pollution outdoors and indoors. It may surprise us that we spend about 80% of our time indoors breathing toxic, stale, polluted air, making us sluggish and fretful. In contrast to outdoor air, indoor air does not recycle consistently.
View Article and Find Full Text PDFMXene, comprised of two-dimensional transition metal carbides/nitride, has emerged as a novel material suitable for environmental remediation of toxic compounds. Due to their inherent and superior physical and chemical properties, MXene is employed in separation techniques like photocatalysis, adsorption, and membrane separation. MXene is equipped with a highly hydrophilic surface, ion exchange property, and robust surface functional groups.
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