Impact of Higher Cell-Free DNA Yields on Liquid Biopsy Testing in Glioblastoma Patients.

Background: Minimally invasive molecular profiling using cell-free DNA (cfDNA) is increasingly important to the management of cancer patients; however, low sensitivity remains a major limitation, particularly for brain tumor patients. Transiently attenuating cfDNA clearance from the body-thereby, allowing more cfDNA to be sampled-has been proposed to improve the performance of liquid biopsy diagnostics. However, there is a paucity of clinical data on the effect of higher cfDNA recovery.

Anti-G evaluations in D- pregnant women determine the need for Rh immune globulin prophylaxis: report of two illustrative cases.

Distinguishing anti-D, anti- C, and anti-G specificities is particularly essential in antenatal cases to ensure proper patient management. The clinical management as well as Rh immune globulin (RhIG) prophylaxis depend on the accurate identification of these distinct antibodies. D- pregnant women with anti-G, but without anti-D, in their serum need RhIG prophylaxis at 28 weeks of gestation, at delivery if the infant is D+, and when clinically indicated to prevent the formation of anti-D and potential hemolytic disease of the fetus and newborn (HDFN).

Historic Land Use Modifies Impacts of Climate and Isolation in Rear Edge European Beech (Fagus sylvatica L.) Populations.

Legacies of human land use have the potential to impact demographic responses to climate. However, few studies have investigated the interactive effects of land use legacies and climate change on tree demography. The demographic performance of rear edge populations in particular is an important determinant of a species' long-term persistence.