Publications by authors named "J Rey"
Cyclic nucleotide-dependent phosphodiesterases (PDEs) play essential roles in regulating the malaria parasite life cycle, suggesting that they may be promising antimalarial drug targets. PDE inhibitors are used safely to treat a range of noninfectious human disorders. Here, we report three subseries of fast-acting and potent PDEβ inhibitors that block asexual blood-stage parasite development and that are also active against human clinical isolates.
View Article and Find Full Text PDFTherapy-induced molecular adaptation of triple-negative breast cancer is crucial for immunotherapy response and resistance. We analyze tumor biopsies from three different time points in the randomized neoadjuvant GeparNuevo trial (NCT02685059), evaluating the combination of durvalumab with chemotherapy, for longitudinal alterations of gene expression. Durvalumab induces an activation of immune and stromal gene expression as well as a reduction of proliferation-related gene expression.
View Article and Find Full Text PDFBackground: BRCA1/2 genes play a critical role in genome stability and DNA repair. In animal models, loss of cardiomyocyte-specific BRCA1/2 is associated with DNA damage, apoptosis, cardiac dysfunction, and mortality following anthracycline exposure. However, whether these preclinical findings translate to humans remains unclear.
View Article and Find Full Text PDFMetallization, a process for applying anti-corrosion coatings, has advantages over hot-dip galvanizing, such as reduced thermal stress and the ability to work "in situ". This process consists of the projection of a protective metal as coating from a wire as application material, and this wire is obtained by multi-stage wiredrawing. For the metallization process, a zinc-aluminum alloy wire obtained by this process is used.
View Article and Find Full Text PDFArticle Synopsis
- HIV-1 inhibitors Bevirimat (BVM) and Lenacapavir (LEN) work by blocking the production and maturation of infectious viral particles, but their exact mechanisms were not well understood due to limited structural data.
- Using perforated virus-like particles from mammalian cells, researchers utilized cryo-electron microscopy to achieve high-resolution structures of HIV-1 with BVM and LEN, marking the first detailed view of these inhibitors interacting with the immature virus.
- The study revealed how BVM binds to the Gag lattice and showed that LEN not only targets the mature capsid but also the immature lattice, causing significant changes in the capsid protein and Gag structure, which might influence the virus's maturation process.