Publications by authors named "J Reszec"
Purpose: The main challenge in maintaining long-term success of endoscopic dacryocystorhinostomy is preventing fibrosis and scarring at the anastomosis site. Despite numerous studies on surgical techniques, research on histological factors linked to postoperative scarring is limited. This study evaluated long-term (range, 12-18 months) outcomes and systematically examined clinical and histopathological factors that may contribute to restenosis.
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- Discrimination between adenocarcinoma (ADC) and squamous cell carcinoma (SCC) in non-small cell lung cancer (NSCLC) is challenging, but lipidomics analysis shows promise in differentiating these subtypes.
- In a study of 25 NSCLC patients, liquid chromatography-mass spectrometry (LC-MS) revealed eight lipid biomarkers that effectively differentiate ADC from SCC, with certain lipids elevated in each group.
- Notably, this research is the first to indicate that plasma levels of lysophosphatidic acids (LPAs) can distinguish between ADC and SCC in NSCLC, highlighting the need for further investigation into their mechanisms and clinical relevance.
Acute lymphoblastic leukemia (ALL) and glioma are some of the most common malignancies, with ALL most often affecting children and glioma affecting adult men. Proangiogenic cytokines and growth factors play an important role in the development of both of these tumors. Glioma is characterized by an extremely extensive network of blood vessels, which continues to expand mainly in the process of neoangiogenesis, the direct inducers of which are cytokines from the family of vascular endothelial growth factors, i.
View Article and Find Full Text PDFAccording to the fifth edition of the WHO Classification of Tumours of the Central Nervous System (CNS) published in 2021, grade 4 gliomas classification includes IDH-mutant astrocytomas and wild-type IDH glioblastomas. Unfortunately, despite precision oncology development, the prognosis for patients with grade 4 glioma remains poor, indicating an urgent need for better diagnostic and therapeutic strategies. Circulating miRNAs besides being important regulators of cancer development could serve as promising diagnostic biomarkers for patients with grade 4 glioma.
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- Lung cancer is a highly studied and lethal type of cancer, particularly focusing on non-small cell lung cancer (NSCLC), which demonstrates significant changes in lipid profiles and redox status among patients.
- Research found that oxidized phosphatidylcholines (oxPCs), derived from the oxidation of membrane phospholipids, can lead to chronic inflammation but may also exhibit anti-inflammatory properties.
- A thorough analysis of nearly 350 plasma and lung tissue samples from NSCLC patients revealed a predominance of long-chain oxPCs in plasma and short-chain oxPCs in tissues, with adenocarcinoma patients showing higher oxPC levels than those with squamous cell carcinoma and control groups.