Publications by authors named "J Rene Thyrian"
Introduction: The societal costs of dementia and cognitive decline are substantial and likely to increase during the next decades due to the increasing number of people in older age groups. The aim of this multicenter cluster-randomized controlled trial was to assess the cost-effectiveness of a multi-domain intervention to prevent cognitive decline in older people who are at risk for dementia.
Methods: We used data from a multi-centric, two-armed, cluster-randomized controlled trial ( trial, ID: DRKS00013555).
Introduction: Health disparities pose a considerable challenge for older adults individuals, particularly those with a heightened risk of developing dementia. Discrepancies in health status among various income brackets are only partially attributable to structural factors such as working and living conditions or the quality of food. The aim of this study was therefore to explore whether and to what extent various health-promoting behaviors can explain the association between household income and self-rated health among older people at risk of dementia.
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- - Germany's healthcare system faces significant challenges in identifying Alzheimer's disease patients eligible for new amyloid-targeting therapies, with projected wait times up to 50 months for specialist visits and PET scans from 2024 to 2043.
- - Patients with social health insurance are expected to endure longer wait times compared to those with private insurance, with peak delays reaching 76 months for social insurance patients and 40 months for private insurance patients.
- - Implementing a blood test as part of the diagnostic process could significantly reduce wait times to under 24 months, highlighting the urgent need for effective triage measures to improve patient access to potentially life-changing treatments.
Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial.
Soc Psychiatry Psychiatr Epidemiol
September 2024
Article Synopsis
- - The AgeWell.de study investigated how social participation can protect against cognitive decline in older adults at risk for dementia, focusing on both the effects of an intervention and other influencing factors over a 24-month period.
- - A total of 819 participants were analyzed using the Lubben Social Network Scale to measure their social connections and types of social activities reported, finding a significant positive impact of the intervention on maintaining higher social participation levels.
- - The results indicated that while the intervention improved the quality of social interactions, the later phases of the Covid-19 pandemic negatively affected social participation, highlighting the importance of enhancing social engagement in dementia prevention strategies.
Article Synopsis
- The study examined the relationship between the CAIDE dementia risk score and modifiable factors in the LIBRA score among 807 German participants at high risk for Alzheimer's.
- Results showed that higher cognitive activity and fruit/vegetable intake were linked to lower CAIDE scores, while diabetes increased risk.
- The findings suggest that different dementia risk scores may classify individuals differently, highlighting the impact of lifestyle choices on dementia risk.