Succinic semialdehyde dehydrogenase deficiency in mice and in humans: An untargeted metabolomics perspective.

Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare neurometabolic disorder caused by disruption of the gamma-aminobutyric acid (GABA) pathway. A more detailed understanding of its pathophysiology, beyond the accumulation of GABA and gamma-hydroxybutyric acid (GHB), will increase our understanding of the disease and may support novel therapy development. To this end, we compared biochemical body fluid profiles from SSADHD patients with controls using next-generation metabolic screening (NGMS).

Single pixel structured imaging through fog.

We describe the application of structured imaging with a single-pixel camera to imaging through fog. We demonstrate the use of a high-pass filter on the detected bucket signals to suppress the effects of temporal variations of fog density and enable an effective reconstruction of the image. A quantitative analysis and comparison of several high-pass filters are demonstrated for the application.

Free space quantum key distribution using modulating retro-reflectors.

Quantum key distribution (QKD) can be used to produce a cryptographic key whose security is guaranteed by quantum mechanics. The range of fiber-based QKD links is limited, by loss, to a few hundred kilometers, and cannot be used between mobile platforms. Free space QKD can, in principle, overcome these limitations.

Statistics and reduction of speckle in optical coherence tomography.

Studies have shown that optical coherence tomography (OCT) is useful in imaging microscopic structures through highly scattering media. Because spatially coherent light is used in OCT, speckle in the reconstructed image is unavoidable, resulting in degradation of the quality of the OCT images and impaired ability to differentiate subsurface structures. Therefore speckle reduction is an important issue in OCT imaging.

Two-dimensional synthetic aperture imaging in the optical domain.

In scan-mode synthetic aperture imaging radar, spatial resolution in a range is given by a frequency-swept waveform, whereas resolution in the orthogonal direction is derived from the record of phase as the beam footprint executes linear motion over the object. We demonstrate here what is to our knowledge the first two-dimensional imaging that uses exactly this process in the optical domain for a 1 cm x 1 cm object with 90 mumx170 mum resolution.