Concomitant dimorphism in poly[di-μ-azido-(5,5'-dimethyl-2,2'-bipyridine)iron(II)].

The title metal-organic polymer, catena-poly[[(5,5'-dimethyl-2,2'-bipyridine-κN,N')iron(II)]-di-μ-azido-κN:N-[(5,5'-dimethyl-2,2'-bipyridine-κN,N')iron(II)]-di-μ-azido-κN:N], [Fe(N)(CHN)], features alternating μ-1,1 (end-on mode of coordination) and μ-1,3 (end-to-end mode of coordination) double azide bridges, forming chains running in the [100] direction. The octahedral coordination geometry around the Fe centre is completed by a bidentate 5,5'-dimethyl-2,2'-bipyridine ligand. Two polymorphs for this compound were obtained from the crude reaction product, the first in the space group P-1 and the other in P2/c.

A rare example of a double metamagnetic transition leading to 2D and 3D long-range order in the two-dimensional pyrazine- and azido-bridged cobalt(II) compound [Co(pyz)(N)].

The synthesis, characterization, crystal structure and detailed magnetic properties of a pyrazine (pyz) and azido (N) bridged cobalt(II) compound of formula [Co(N)(pyz)] (1) are reported. Compound 1 shows a layered structure formed by Co(II) chains with double μ-N(κN,N) bridges that are further connected by μ-(pyrazine-κN,N) bridges. The layers present weak van der Waals interactions between azido terminal groups.

An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt Linker Lx for Improved Manufacturability of Antibody-Drug Conjugates.

The Pt linker [ethylenediamineplatinum(II)] , coined Lx, has emerged as a novel non-conventional approach to antibody-drug conjugates (ADCs) and has shown its potential in preclinical in vitro and in vivo benchmark studies. A crucial improvement of the Lx conjugation reaction from initially <15 % to ca. 75-90 % conjugation efficiency is described, resulting from a systematic screening of all relevant reaction parameters.

Fifty years of inorganic biochemistry: Developments, trends, highlights, impact and citations.

A brief historic overview and analysis is presented of the almost 9000 scientific articles that have appeared in the Journal of Inorganic Biochemistry (JIB) and its predecessor (Bioinorganic Chemistry), since 1973. This overview has a focus on the different topics, in particular on the different elements of the Periodic Table and on papers that have received very large numbers of citations. Over the whole period, copper has been the element occurring in most publications (almost 1800, which is 20%), followed by iron which occurs in some 12% of all papers.

Transition-metal norharmane compounds as possible cytotoxic agents: New insights based on a coordination chemistry perspective.

New first-row transition-metal compounds with the ligand norharmane (9H-Pyrido[3,4-b]indole; Hnor) are reported. The compounds have the general formula [M(LL)(Hnor)(NO)](MeOH) (M=Co, Ni, Cu, Zn; LL=2,2'-bipyridyl (bpy), 1,10-phenanthroline (phen)) and have been characterized by physical and analytical methods. X-ray structural analysis revealed that the compound of formula [Cu(phen)(Hnor)(NO)], (1) has a distorted 6-coordinated octahedrally-based geometry, with a planar-based [CuNO] core, where Cu-L varies between 1.