Publications by authors named "J Raymer"

Background: The Endometriosis Health Profiles (EHPs), the EHP-30 and EHP-5, are patient-reported outcome measures that were developed to measure the health-related quality of life (HRQoL) of women living with endometriosis. Prior to their development, a systematic review was undertaken which identified that the HRQoL of women living with endometriosis was poorly understood, with only three medical and one surgical study identified.

Objective And Rationale: The 20-year anniversary of the EHP-30 provided a timely opportunity to assess how the tools have been used and explore what the findings tell us about the impact of endometriosis and its associated treatments upon women's QoL.

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Humans show remarkable habituation to aversive events as reflected by changes of both subjective report and objective measures of stress. Although much experimental human research focuses on the effects of stress, relatively little is known about the cascade of physiological and neural responses that contribute to stress habituation. The cold pressor test (CPT) is a common method for inducing acute stress in human participants in the laboratory; however, there are gaps in our understanding of the global state changes resulting from this stress-induction technique and how these responses change over multiple exposures.

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International migration is an important source of population change and economic development for Pacific Island countries. Migration from the Pacific Island region contributes to labour recruitment in countries like Australia, New Zealand and the United States. However, there are substantial gaps in the understanding of overall migration patterns in this region, impeding the development of relevant policies.

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Article Synopsis
  • AAV vectors are effective for gene transfer due to their variety of serotypes that target different cells.
  • Two strategies to enhance AAV vectors include rational design, which modifies capsids based on structural knowledge, and directed evolution, which uses random mutation techniques.
  • The study highlights new AAV2 and AAV5 variants created through rational design that show improved effectiveness in targeting mouse and nonhuman primate retinal tissues, suggesting potential for treating ocular diseases.
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