Response to Central Boost Radiation Therapy in Unresectable Retroperitoneal Sarcoma: A Case Series.

Purpose: Optimal treatment of retroperitoneal sarcoma (RPS) remains undefined. Here, we report the feasibility of using high-dose boost radiation (3-4 Gy) to the central part of the tumor in patients with unresectable RPS.

Methods And Materials: Five patients with unresectable RPS were treated with radiation therapy using a central boost technique with intensity modulated radiation therapy.

In silico drug repurposing at the cytoplasmic surface of human aquaporin 1.

Aquaporin 1 (AQP1) is a key channel for water transport in peritoneal dialysis. Inhibition of AQP1 could therefore impair water transport during peritoneal dialysis. It is not known whether inhibition of AQP1 occurs unintentionally due to off-target interactions of administered medications.

Surgical Obliteration of a Filum Terminale Arteriovenous Fistula Following Aborted Endovascular Embolization: Illustrative Case Report and Literature Review.

Arteriovenous fistulas of the filum terminale are rare vascular malformations that predominantly affect males and can present with various neurological symptoms. In this study, we indexed previously published cases of filum terminale arteriovenous fistulas demonstrating that endovascular and microsurgical management are both proven to be appropriate and successful treatment modalities with low complication rates. Endovascular treatment is far less invasive; however, it is associated with higher failure rates, which need to be managed surgically.

Navigating the Complexity of Stiff Person Syndrome: A Case Report and Literature Review.

Stiff person spectrum disorder is a disease that involves a host of conditions that are associated with glutamic acid decarboxylase 65-kilodalton isoform autoantibodies. These conditions may include diabetes mellitus type 1, pernicious anemia, autoimmune leukoencephalopathy, cerebellar ataxia, and stiff-person syndrome. Clinical recognition and diagnosis of stiff person spectrum disorder are important early, as immunologic treatment options showing reliable efficacy in slowing disease progression are available.

Revealing the Baja California Peninsula's Hidden Treasures: An Annotated checklist of the native bees (Hymenoptera: Apoidea: Anthophila).

To date, the knowledge of bee diversity in the Baja California Peninsula has primarily relied on large, sporadic expeditions from the first half of the 20th century. To address the knowledge gaps, we conducted extensive fieldwork from 2019 to 2023, visited entomological collections in Mexico and USA, and accessed digital databases and community science platforms to compile records. As a result of our field surveys, we identified 521 morphospecies, with 350 recognized as valid species, including 96 new records for the Baja California Peninsula and 68 new findings for Mexico, including the rediscovery of Megachile seducta Mitchell, 1934, ranked as possibly extinct.