Publications by authors named "J Ralston"
Background: Anticholinergic exposure is associated with dementia risk; however, the mechanisms for this association remain unclear. The objective of this study was to examine the association between anticholinergic exposure and white matter hyperintensity (WMH) burden.
Methods: This was a retrospective analysis of data from the Adult Changes in Thought (ACT) study, a prospective cohort study among adults aged ≥65 years on dementia risk factors.
Tractometry of diffusion-weighted magnetic resonance imaging (dMRI) non-invasively quantifies tissue properties of brain connections. It is widely used in aging studies but could be less reliable in aging brains due to increased white matter free water. We demonstrate that computational free water elimination (FWE) increases reliability and accuracy of tractometry in a large (n = 339) cohort of older adults (66 - 103 y.
View Article and Find Full Text PDFPurpose: Patient portal use may improve access to or use of sexual and reproductive health (SRH) services for adolescents. We examined the association between adolescent secure messaging on a portal and use of SRH services in one health system.
Methods: We conducted a retrospective cohort study using electronic health records of adolescents aged 13-17 at Kaiser Permanente Washington from 2019 to 2021.
Article Synopsis
- - The study aimed to discover how common undiagnosed malignant tumors are in healthy middle-aged to older dogs, specifically those aged 5.5 to 11.5 years.
- - Out of 902 screened dogs, 2.7% were diagnosed with cancer, while an additional 3.3% had abnormalities that could indicate malignancy, raising the total to 6.0% when including suspected cases.
- - The findings highlight that thorough physical exams, especially with aspiration cytology, are essential for effectively screening for cancer in older dogs.