Remote Hydrogen Bonding between Ligand and Substrate Accelerates C-H Bond Activation and Enables Switchable Site Selectivity.

Transition-metal-catalyzed selective and efficient activation of an inert C-H bond in an organic substrate is of importance for the development of streamlined synthetic methodologies. An attractive approach is the design of a metal catalyst capable of recognizing an organic substrate through noncovalent interactions to control reactivity and selectivity. We report here a spirobipyridine ligand that bears a hydroxy group that recognizes pyridine and quinoline substrates through hydrogen bonding, and in combination with an iridium catalyst enables site-selective C-H borylation.

A web portal for exploring kinase-substrate interactions.

Interactions between protein kinases and their substrates are critical for the modulation of complex signaling pathways. Currently, there is a large amount of information available about kinases and their substrates in disparate public databases. However, these data are difficult to interpret in the context of cellular systems, which can be facilitated by examining interactions among multiple proteins at once, such as the network of interactions that constitute a signaling pathway.

A novel approach for heart disease prediction using hybridized AITHO algorithm and SANFIS classifier.

In today's world, heart disease threatens human life owing to higher mortality and morbidity across the globe. The earlier prediction of heart disease engenders interoperability for the treatment of patients and offers better diagnostic recommendations from medical professionals. However, the existing machine learning classifiers suffer from computational complexity and overfitting problems, which reduces the classification accuracy of the diagnostic system.

Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance.

Mucosal barrier integrity is vital for homeostasis with commensal organisms while preventing pathogen invasion. We unexpectedly found that fungal-induced immunosurveillance enhances resistance to fungal outgrowth and tissue invasion by remodeling the oral mucosal epithelial barrier in mouse models of adult and neonatal colonization. Epithelial subset expansion and tissue remodeling were dependent on interleukin-22 (IL-22) and signal transducer and activator of transcription 3 (STAT3) signaling, through a non-canonical receptor complex composed of glycoprotein 130 (gp130) coupled with IL-22RA1 and IL-10RB.

Deciphering the impact of on human health, and exploration of natural compounds as efflux pump inhibitors to treat multidrug resistance.

is an ESKAPE pathogen and threatens human health by generating infections with high fatality rates. leads to a spectrum of infections such as skin and wound infections, endocarditis, meningitis pneumonia, septicaemia and urinary tract infections. Recently, strains of have emerged as multidrug-resistant (MDR), meaning they are resistant to at least three different classes of antibiotics.