A Retrospective Analysis of Epidemiological Factors and Surgical Outcomes of Patients With Ocular Trauma at Hospital Kuala Lumpur, Malaysia.

Background The objective of this review is to study the demographics, aetiology, clinical findings, and surgical outcomes of patients who presented with ocular trauma and underwent emergency operations at Hospital Kuala Lumpur, Malaysia. Methods Patients who presented from 2016 to 2023 with ocular trauma and underwent emergency ocular surgery were identified and their medical records were reviewed with respect to demographics, mechanism of injury, type of injury, initial presenting visual acuity and final visual acuity after surgery. Components of the ocular trauma score (OTS) were also recorded.

Loss of Glutathione-S-Transferase Theta 2 (GSTT2) Modulates the Tumor Microenvironment and Response to BCG Immunotherapy in a Murine Orthotopic Model of Bladder Cancer.

Loss of the glutathione-S-transferases Theta 2 (Gstt2) expression is associated with an improved response to intravesical , Bacillus Calmette-Guérin (BCG) immunotherapy for non-muscle-invasive bladder cancer (NMIBC) patients who receive fewer BCG instillations. To delineate the cause, Gstt2 knockout (KO) and wildtype (WT) C57Bl/6J mice were implanted with tumors before treatment with BCG or saline. RNA was analyzed via single-cell RNA sequencing (scRNA-seq) and real-time polymerase chain reaction (RT-PCR).

Regulatory genome annotation of 33 insect species.

Annotation of newly sequenced genomes frequently includes genes, but rarely covers important non-coding genomic features such as the -regulatory modules-e.g., enhancers and silencers-that regulate gene expression.

Glutathione-S-Transferase Theta 2 (GSTT2) Modulates the Response to Bacillus Calmette-Guérin Immunotherapy in Bladder Cancer Patients.

Glutathione-S-transferases (GST) enzymes detoxify xenobiotics and are implicated in response to anticancer therapy. This study evaluated the association of GST theta 1 (GSTT1), GSTT2, and GSTT2B with Mycobacterium bovis Bacillus Calmette-Guérin (BCG) response in non-muscle-invasive bladder cancer treatment. In vitro assessments of GSTT2 knockout (KO) effects were performed using cell lines and dendritic cells (DCs) from GSTT2KO mice.