Publications by authors named "J Radonak"
Article Synopsis
- Pancreatic cancer is a severe disease with low survival rates, prompting research into non-invasive screening methods like biomarkers to aid early detection.
- The study followed 46 patients, measuring levels of MMP9 in their serum and tissue, revealing elevated levels at advanced stages of the disease.
- While MMP9 could be useful for identifying late-stage pancreatic cancer, the study did not find a correlation between MMP9 levels and earlier disease stages, possibly due to the small sample size.
Despite advances in the genomic classification of breast cancer, current clinical tests and treatment decisions are commonly based on protein-level information. Nowadays breast cancer clinical treatment selection is based on the immunohistochemical (IHC) determination of four protein biomarkers: Estrogen Receptor 1 (ESR1), Progesterone Receptor (PGR), Human Epidermal Growth Factor Receptor 2 (HER2), and proliferation marker Ki-67. The prognostic correlation of tumor-infiltrating T cells has been widely studied in breast cancer, but tumor-infiltrating B cells have not received so much attention.
View Article and Find Full Text PDFBackground: In the 21st century, endoscopic retrograde cholangiopancreatography (ERCP) has emerged as a diagnostic and therapeutic method for diseases of the pancreaticobiliary duct system. However, like any other diagnostic and therapeutic method, ERCP carries the risk of unwanted complications.
Material And Methods: We retrospectively followed patients who underwent ERCP examinations from January 2013 to April 2023.
Peripheral blood CD8 T lymphocytes play a crucial role in cell-mediated immunity and tumor-related immune responses in breast cancer. In this study, label-free quantification analysis and gene set enrichment analysis (GSEA) of CD8 T lymphocytes in the peripheral blood of benign patients and patients with different breast cancer (BC) subtypes, i.e.
View Article and Find Full Text PDFArticle Synopsis
- This study compares two surgical methods, Hartmann's procedure (HP) and resection with primary anastomosis (RPA), for treating acute left-sided colonic emergencies among 1215 patients from 204 centers globally.
- Results showed that while HP was the more common treatment (57.3%), RPA was favored for younger patients with fewer health issues and those needing surgery sooner.
- The study concluded that although HP is still widely used, RPA might be the better option, emphasizing the importance of patient characteristics and surgeon experience in determining treatment choice.