Publications by authors named "J Raab"
Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed millions of lives. The imminent threat of a panzootic outbreak of avian influenza H5N1 virus underscores the urgent need for pandemic preparedness and effective countermeasures, including monoclonal antibodies (mAbs). Here, we characterize human mAbs that target the highly conserved catalytic site of viral neuraminidase (NA), termed NCS mAbs, and the molecular basis of their broad specificity.
View Article and Find Full Text PDFUnlabelled: Type 3 secretion systems (T3SSs) enable bacterial virulence by translocating virulence proteins (effectors) into host cells. require T3SS to invade and to spread between cells in the colon. In order to spread, forms membrane protrusions that push into the adjacent host cell.
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- Aberrant expression of the associated protein 1 tumor suppressor gene is a significant risk factor for various tumors, playing a crucial role in tumor evolution and progression.
- The study utilized data from The Cancer Genome Atlas covering 33 cancer types and over 10,000 individuals to detect genetic alterations, leading to a 41% increase in the identification of somatic variants.
- The research revealed a transcriptional profile linked to tumor disruption and highlighted the gene's impact on cellular plasticity and cell identity, indicating that loss of function in normal cells correlates with less differentiated characteristics in embryonic cells.
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- STAT3 gain-of-function syndrome is an immune disorder that results in various immune system issues, often requiring immunomodulatory treatments like blocking interleukin-6 receptors or using JAK inhibitors (JAKi).
- A study at Hannover University involved seven patients with STAT3-GOF, where five were treated with JAK inhibitors, leading to positive outcomes for many autoimmune and inflammatory symptoms.
- Overall, JAKi treatment showed significant improvement for the majority of patients, but more long-term studies are necessary to understand the risks associated with extended use.
What Is This Summary About?: This summary describes how researchers worked with people with multiple sclerosis (MS), neurologists and measurement experts to create an easy-to-use questionnaire to measure the physical function of people with MS. This questionnaire covers topics that are relevant and important to people with MS and their doctors.The ability to do what you want to do, when you want to do it, is one of the most important concerns for people with MS.
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