Publications by authors named "J RANSOHOFF"
Article Synopsis
- Stromal tumor-infiltrating lymphocyte (sTIL) levels in breast tumors are linked to better responses to neoadjuvant treatment and improved survival rates.
- A study found no racial or ethnic differences in sTIL scores; however, higher sTIL scores were tied to lower breast cancer-specific mortality primarily in non-Hispanic White and Asian American women.
- The results indicate that sTIL enrichment does not provide the same survival benefits for African American and Hispanic women, highlighting the need for more research on treatment strategies that consider health disparities among different racial and ethnic groups.
Article Synopsis
- Antimicrobial exposure during treatment of triple-negative breast cancer (TNBC) is linked to gut microbiome changes and lower lymphocyte counts, which may result in worse patient outcomes.
- A study analyzed data from 772 women with stage I-III TNBC and found that 85% had used antimicrobials, and each additional prescription correlated with decreased survival rates.
- These findings suggest that past antimicrobial use negatively affects TNBC survival independently of disease severity and emphasizes the need for careful antimicrobial prescribing in cancer treatment.
PIONEER is a European network of excellence for big data in prostate cancer consisting of 37 private and public stakeholders from 9 countries across Europe. Many progresses have been done in prostate cancer management, but unanswered questions in the field still exist, and big data could help to answer these questions. The PIONEER consortium conducted a two-round modified Delphi survey aiming at building consensus between two stakeholder groups - health-care professionals and patients with prostate cancer - about the most important questions in the field of prostate cancer to be answered using big data.
View Article and Find Full Text PDFBackground: AKI is an abrupt decrease in kidney function associated with significant morbidity and mortality. Electronic notifications of AKI have been utilized in patients who are hospitalized, but their efficacy in the outpatient setting is unclear.
Methods: We evaluated the effect of two outpatient interventions: an automated comment on increasing creatinine results (intervention I; 6 months; =159) along with an email to the provider (intervention II; 3 months; =105), compared with a control (baseline; 6 months; =176).
Background: Women with intellectual and developmental disabilities face poorer reproductive and pregnancy outcomes partially due to health care inequity. Our objective was to conduct a scoping review of reproductive and pregnancy related health care among women with intellectual and developmental disabilities.
Methods: We systematically reviewed three databases for keywords pertaining to pregnancy, reproductive health, and intellectual and developmental disabilities.