Urocanic acid as a novel scaffold for next-gen nature-inspired sunscreens: II. Time-resolved spectroscopy under solution conditions.

In recent years the use of synthetic UV filters in commercial skincare formulations has come under considerable scrutiny. Urocanic acid is a naturally occurring UV filter that could serve as a scaffold for developing next-generation biomimetic UV filters. We have carried out time-resolved electronic and vibrational absorption studies on urocanic acid and modified variants in various solvents on timescales spanning eighteen orders of magnitude; from femtoseconds to hours.

Modern Multidisciplinary Management of Soft Tissue Sarcoma of the Extremity and Trunk.

Soft tissue sarcomas (STS) of the extremity and trunk are heterogeneous and rare tumors that require coordinated multidisciplinary management. Surgical resection remains the backbone of treatment for localized tumors, with the addition of radiotherapy to surgery to achieve high rates of local control. Despite this, overall survival is limited because of significant distant metastatic risk and a lack of efficacious systemic therapies.

Pediatric versus Adult Medulloblastoma: Towards a Definition That Goes beyond Age.

Medulloblastoma is a rare malignant brain tumor that predominantly affects children but also occurs in adults. The incidence declines significantly after age 15, and distinct tumor molecular features are seen across the age spectrum. Standard of care treatment consists of maximal safe surgical resection followed by adjuvant radiation and/or chemotherapy.

Comparison of the Bentall procedure versus valve-sparing aortic root replacement.

Bentall and valve-sparing root replacement (VSRR) procedures are established treatments for aortic root disease. We present a single-center retrospective analysis comparing outcomes of bioprosthetic Bentall (BB), mechanical Bentall (MB), and VSRR patients from November 2007 to October 2016. Survival analysis was performed to evaluate the composite endpoint of freedom from recurrent aortic insufficiency, reoperation, or death.