Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration.

Purpose: To investigate the safety, tolerability, and efficacy of intravitreal injection of galegenimab, an anti-HtrA1 FAb, in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

Design: Phase 2, single-masked, randomized clinical trial.

Methods: Eligible GA patients with BCVA letter scores of ≥ 24 letters and baseline GA lesion size 2.

Pervasive conservation of intron number and other genetic elements revealed by a chromosome-level genome assembly of the hyper-polymorphic nematode Caenorhabditis brenneri.

With within-species genetic diversity estimates that span the gamut of that seen across the entirety of animals, the Caenorhabditis genus of nematodes holds unique potential to provide insights into how population size and reproductive strategies influence gene and genome organization and evolution. Our study focuses on Caenorhabditis brenneri, currently known as one of the most genetically diverse nematodes within its genus and, notably, across Metazoa. Here, we present a high-quality, gapless genome assembly and annotation for C.

A Mediterranean-style diet protects against cognitive and behavioral deficits, adiposity, and Alzheimer's disease-related markers, compared to a macronutrient-matched typical American diet in C57BL/6J mice.

BackgroundResearch suggests that modifying risk factors may prevent or delay up to 40% of dementia cases, including Alzheimer's disease (AD). Thus, understanding the potential of healthful dietary patterns, like the Mediterranean diet (MD), in AD prevention is crucial. While supplementation of Mediterranean foods has demonstrated efficacy in reducing AD biomarkers and cognitive impairment in rodents, the effects of a MD warrant further investigation.

Rotator Cuff Footprint Medialization: Indications and Technique.

When attempting to repair a large, retracted rotator cuff tear, the orthopaedic surgeon can use several techniques such as capsular release and interval slides that can aid in achieving a low-tension repair and thus allow the best environment for healing. One less commonly used strategy is medialization of the greater and lesser tuberosity anatomic rotator cuff footprint. Previous studies have shown that increased tension across the bone-tendon interface decreases healing rates.

Cultured and molecular measures of fecal indicator microbes in Gulf of Mexico recreational waters.

Recreational waters are routinely assessed by enumeration of fecal indicator bacteria, such as enterococci, but research suggests viral indicators may be better suited for recreational water quality applications. Somatic and F+ coliphage were proposed as predictors of viral pathogens in recreational waters, but concurrent measurements of enterococci and coliphages and comparisons across different risk-based beach action values (BAVs) are limited. We collected paired measurements of enterococci, E.