Publications by authors named "J R Willcox"
Background: Alzheimer's disease (AD) is a devastating form of dementia, and its prevalence is rising as human lifespan increases. Our lab created the AD-BXD mouse model, which expresses AD mutations across a genetically diverse reference panel (BXD), to identify factors that confer resilience to cognitive decline in AD. This model mimics key characteristics of human AD including variation in age of onset and severity of cognitive decline.
View Article and Find Full Text PDFPurpose: Many medical students in the U.S. lack formal exposure to radiation oncology (RO).
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- - The study aimed to discover how common undiagnosed malignant tumors are in healthy middle-aged to older dogs, specifically those aged 5.5 to 11.5 years.
- - Out of 902 screened dogs, 2.7% were diagnosed with cancer, while an additional 3.3% had abnormalities that could indicate malignancy, raising the total to 6.0% when including suspected cases.
- - The findings highlight that thorough physical exams, especially with aspiration cytology, are essential for effectively screening for cancer in older dogs.
Data regarding the outcome of canine rib chondrosarcoma is sparse and varied. While grade of tumour is associated with outcome for canine appendicular chondrosarcoma, the association of grade with outcome for canine rib chondrosarcoma is unclear. This study aimed to correlate the grade of canine rib chondrosarcoma with median survival time.
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- A scoping review examined barriers and enablers to effective weight management for individuals with obesity in high-income countries, analyzing 216 relevant studies.
- Three main themes identified were healthcare provider-related factors, the provision of care, and policy/funding issues.
- Key barriers included lack of provider knowledge and prioritization of obesity management, while enablers highlighted the need for improved education, consistent policies, and increased funding for comprehensive care.