Responses to the activation of different intranasal trigeminal receptors: Evidence from behavioral, peripheral and central levels.

Aim: There are various receptors that mediate intranasal trigeminal sensations. However, few studies compare the response patterns across different receptor activations.

Methods: We recorded negative mucosal potentials (NMPs) in 24 healthy participants and event-related potentials (ERPs) in 17 participants during exposure to five odors that trigger trigeminal sensations and one olfactory stimulus.

Neural Processing of Odors with Different Well-Being Associations-Findings from Two Consecutive Neuroimaging Studies.

Much is known about the effect of odors on mood, cognition and behavior, but little is known about the relationship between odors and well-being. We investigated the neural processing of odors with different degrees of association with well-being (WB) through two large independent datasets. The study encompassed pre-testing and fMRI.

Effects of odors on sleep quality in 139 healthy participants.

The present study aimed to systematically examine whether laurinal, orange odor, and a specifically designed "perfume" influence sleep quality. During sleep, healthy participants (n = 139) were presented with odor or no odor through nose clips for fourteen consecutive nights (phase one). We collected physiological parameters together with subjective reports.

Tractography indicates lateralized differences between trigeminal and olfactory pathways.

Odorous sensations are based on trigeminal and olfactory perceptions. Both trigeminal and olfactory stimuli generate overlapping as well as distinctive activations in the olfactory cortex including the piriform cortex. Orbitofrontal cortex (OFC), an integrative center for all senses, is directly activated in the presence of olfactory stimulations.

Habitual Exposure to Trigeminal Stimuli and Its Effects on the Processing of Chemosensory Stimuli.

Our objective was to compare brain responses to trigeminal and olfactory stimuli in frequent and non-frequent gum chewers in order to explore whether habitual exposure to trigeminal stimuli affects their central-nervous processing. In healthy subjects, fMRI brain scans were obtained for 20 frequent gum chewers (GC) and 20 non-frequent gum chewers (N'GC), in response to four odorous stimuli; 2 'trigeminal' (peppermint and spearmint) and 2 non-trigeminal or 'olfactory' (cherry and strawberry). During measurements, subjects reported intensity and pleasantness ratings for all stimuli.