Publications by authors named "J R Warmington"
The incidence of human infections by the fungal pathogen Candida species has been increasing in recent years. Enolase is an essential protein in fungal metabolism. Sequence data is available for human and a number of medically important fungal species.
View Article and Find Full Text PDFExtended assessments of memory T-cell responses in HIV patients who have a satisfactory virological response to combination antiretroviral therapy (CART) have been limited by availability of longitudinal samples and of antigens to which most individuals (including HIV-negative controls) have been exposed. Studies of cytomegalovirus (CMV) show that interferon-gamma (IFN-gamma) responses never recover completely, but this may be antigen-specific. Here we present responses to Candida and CMV antigens analyzed using a statistical approach that derives overall trends from samples collected at variable time points.
View Article and Find Full Text PDFArticle Synopsis
- The study tested anti-Candida antibodies in 76 immunocompetent and 293 immunocompromised individuals.
- For the immunocompetent group, test sensitivity was 74% and specificity was 75%, while for the immunocompromised group, sensitivity dropped to 15% and specificity was 60%.
- The negative predictive value was high (93%) in the immunocompromised group, highlighting Syscan3's effectiveness in ruling out invasive candidiasis.