Publications by authors named "J R Torrisi"
Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content.
Angew Chem Int Ed Engl
January 2025
Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor.
View Article and Find Full Text PDFPurpose: Even though BRAF fusions are increasingly detected in standard multigene next-generation sequencing panels, few reports have explored their structure and impact on clinical course.
Experimental Design: We collected data from patients with BRAF fusion-positive cancers identified through a genotyping protocol of 97,024 samples. Fusions were characterized and reviewed for oncogenic potential (in-frame status, non-BRAF partner gene, and intact BRAF kinase domain).
The impact of implementation of rapid blood culture identification panels on antimicrobial optimization: a retrospective cohort study.
Antimicrob Steward Healthc Epidemiol
April 2024
Objective: Determine the impact of limited implementation of a rapid blood culture identification (BCID) panel.
Design: Retrospective cohort study.
Methods: From February to April 2022, positive blood cultures identified via e-Plex BCID (Roche, Carlsbad, CA) were compared to those identified using standard microbial identification techniques.
Article Synopsis
- This study focused on the incidence and treatment outcomes of disseminated Bartonella spp. infections, which are typically diagnosed using molecular tests like PCR due to limitations in traditional culture methods.
- The research analyzed data from patients diagnosed with bartonellosis between 2014 and 2021, primarily identifying Bartonella henselae as the responsible pathogen, with doxycycline and rifampin being the most common treatment.
- Results showed a notable 39% treatment failure rate, highlighting the importance of using various diagnostic tests and understanding treatment options for managing these infections.
A general strategy for the synthesis of 2,4'-disubstituted glycoluril enantiomers on a multigram scale using orthogonal protection is reported. The use of these glycolurils is demonstrated in the synthesis of enantiomerically pure bambus[6]uril macrocycles. Moreover, the deprotection of ()-1-phenylethyl substituents on the macrocycle was achieved, opening access to various chiral bambus[6]urils post-macrocyclization modification strategy.
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