House Mice in the Atlantic Region: Genetic Signals of Their Human Transport.

Background/objectives: The colonization history of house mice reflects the maritime history of humans that passively transported them worldwide. We investigated western house mouse colonization in the Atlantic region through studies of mitochondrial D-loop DNA sequences from modern specimens.

Methods: We assembled a dataset of 758 haplotypes derived from 2765 mice from 47 countries/oceanic archipelagos (a combination of new and published data).

Biodiversity conservation, consistency, and Mus musculus.

The house mouse (Mus musculus) is often thought of as a pest species in biological conservation, in agriculture, and in urban areas. As a result, populations are frequently targeted for control and eradication. However, M.

Meiotic Drive and Speciation.

Meiotic drive is the biased transmission of alleles from heterozygotes, contrary to Mendel's laws, and reflects intragenomic conflict rather than organism-level Darwinian selection. Theory has been developed as to how centromeric properties can promote female meiotic drive and how conflict between the X and Y chromosomes in males can promote male meiotic drive. There are empirical data that fit both the centromere drive and sex chromosome drive models.

The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRAS-driven non-small cell lung cancer.

Introduction: KRAS and KRAS inhibitors represent a major translational breakthrough for non-small cell lung cancer (NSCLC) and cancer in general by directly targeting its most mutated oncoprotein. However, resistance to these small molecules has highlighted the need for rational combination partners necessitating a critical understanding of signaling downstream of KRAS mutant isoforms.

Methods: We contrasted tumor development between Kras and Kras genetically engineered mouse models (GEMMs).