Evaluation of the Sysmex CN-6000 Coagulation Analyzer for Routine and Specialized Coagulation Testing in a Central Laboratory.

Background: The Sysmex CN-6000 is a fully automated high-throughput coagulation analyzer. The objective of this study was to evaluate the analytical performance of the analyzer for routine and special coagulation testing in a high-throughput central laboratory of a university hospital.

Methods: The within- and between-day precision and accuracy of 29 coagulation parameters were evaluated on the Sysmex CN-6000 using commercially available quality control materials.

Validating Room Location within the Home for Functional Measures from Digital Health Technologies.

Digital health technologies have the potential to measure how a patient feels and functions with low patient burden e.g.: to provide real-world evidence of the benefit of a novel treatment.

Fine-Tuning of ATF4 DNA Binding Activity by a Secondary Basic Motif Unique to the ATF-X Subfamily of bZip Transcription Factors.

The fine-tuning of transcription factor DNA-binding activity is often governed by transient intramolecular interactions between the transactivation domain and the DNA-binding domain. An example of such interaction is found in the transcription factor ATF4, a central regulator of the Integrated Stress Response. In ATF4, dynamic coupling between the transactivation domain and the basic-leucine zipper (bZip) domain modulates the phosphorylation levels of the disordered transactivation domain by casein kinase 2.

A comparison on the efficiency and safety between two morcellators for laser enucleation of the prostate: Piranha versus Cyber Blade. A randomized controlled trial.

Background: We performed a comparison between the Wolf Piranha and the Quanta System Cyber Blade morcellators for the Thulium laser enucleation of the prostate (ThuLEP).

Methods: Overall, 205 patients underwent ThuLEP in three urologic departments (Como, Bordeaux, Madrid). Patients were randomized to Piranha morcellator with disposable blades (100 cases, Group A) or Cyber Blade morcellator (105 cases, Group B).

Ejaculation-sparing enucleation of the prostate with Thulium: Yag laser (ES-ThuLEP) versus Thulium Fiber laser (ES-ThuFLEP): outcomes on sexual function.

Purpose: To compare the effect on sexual function of ejaculation-sparing enucleation of the prostate using Thulium: YAG laser (ES-ThuLEP) versus continuous-wave Thulium Fiber Laser (ES-ThuFLEP).

Methods: 112 patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia who wished to preserve ejaculation were treated. 58 patients underwent ES-ThuLEP (Group A) using the Cyber TM generator.