Publications by authors named "J R Resser"
Background: (pneumococcus) causes invasive pneumococcal disease (IPD) and non-invasive acute respiratory infections (ARIs). Three pneumococcal conjugate vaccines (PCVs) are recommended in the United States with additional products in clinical trials. We aimed to estimate 1) proportions of IPD cases and pneumococcal ARIs caused by serotypes targeted by existing and pipeline PCVs and 2) annual U.
View Article and Find Full Text PDFCost-Benefit Analysis of a Pediatric ICU Sedation Weaning Protocol.
J Pediatr Pharmacol Ther
October 2024
Article Synopsis
- A retrospective study in a pediatric intensive care unit assessed the impact of a risk stratified sedation weaning protocol on medication costs and patient outcomes over a two-year period.
- The results showed that implementing the protocol reduced total sedation weaning costs significantly from approximately $400,329 to around $170,459, with lower median costs per patient.
- Despite the cost reduction, the incidence of withdrawal symptoms before and after the protocol remained similar, indicating that patient outcomes were not adversely affected by the change.
Article Synopsis
- * A study conducted between September 2018 and October 2022 in Tennessee and Georgia found that 12.1% of hospitalized adults with CAP had Streptococcus pneumoniae detected, with the most common serotypes being 3, 22F, 19A, and others.
- * Findings suggest that a significant portion of detected serotypes, approximately one-third, are not covered by current vaccines like PCV15 and PCV20, indicating the need for new vaccines with broader serotype coverage to reduce disease occurrence.
Background: Delayed mortality in sepsis often is linked to a lack of resolution in the inflammatory cascade termed persistent inflammation, immunosuppression, and catabolism syndrome (PICS). Limited research exists on PICS in pediatric patients with sepsis.
Research Question: What is the prevalence of pediatric PICS (pPICS) in patients who died of sepsis-related causes and what associated pathogen profiles and comorbidities did they have compared with those patients without pPICS who died from sepsis?
Study Design And Methods: A retrospective study of a single institution using a de-identified database from 1997 through 2020 for all patients aged 21 years or younger who died of culture-positive sepsis from a known source and who had laboratory data available were evaluated for the presence of pPICS.
Objective: To evaluate and compare the efficacy of the Semont liberatory maneuver on "objective" benign paroxysmal positional vertigo (BPPV) defined as vertigo with geotropic nystagmus in Dix-Hallpike positioning versus "subjective" BPPV defined as vertigo without nystagmus in Dix-Hallpike positioning.
Study Design: Retrospective chart review.
Methods: One hundred sixty-two patients with positional vertigo during Dix- Hallpike positioning were identified.