Publications by authors named "J R Philpott"
The significance of multiplication rate variation in malaria parasites needs to be determined, particularly for Plasmodium falciparum, the species that causes most virulent infections. To investigate this, parasites from cases presenting to hospital in The Gambia and from local community infections were culture-established and then tested under exponential growth conditions in a standardised six-day multiplication rate assay. The multiplication rate distribution was lower than seen previously in clinical isolates from another area in West Africa where infection is more highly endemic.
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- A human lectin array has been developed to study how immune receptors interact with various microbes, featuring C-type carbohydrate-recognition domains (CRDs) and other sugar-binding receptors like galectins and siglecs.
- The array is designed using biotin-tagged CRDs, allowing for easy detection of binding interactions on a streptavidin-coated surface, facilitating comparisons across different types of glycan-binding receptors.
- Initial tests show unexpected binding patterns, revealing that some galectins interact strongly with bacterial glycans, highlighting the array's potential to provide new insights into innate immune interactions with diverse microorganisms.
Purpose Of Review: Gastrointestinal (GI) dysfunction limits enteral nutrition (EN) delivery in critical illness and contributes to systemic inflammation. The enteroendocrine (EE) axis plays an integral role in this interface between nutrition, inflammation, and GI function in critical illness. In this review, we present an overview of the EE system with a focus on its role in GI inflammation and function.
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- The study examines the relationship between the type of surgical approach (primary anastomosis vs. intended temporary diversion) and the risk of recurrence in patients with Crohn's disease after surgery.
- The research involved 793 Crohn's disease patients over a median follow-up of 44 months, revealing a high postoperative recurrence rate of 83.3%.
- It also analyzes the impact of timing for biologic treatment on recurrence, specifically in patients who underwent temporary diversion, highlighting factors such as sex, disease characteristics, and previous treatment history that influenced outcomes.
Background: Since 2009, inflammatory bowel disease (IBD) specialists have utilized "IBD LIVE," a weekly live video conference with a global audience, to discuss the multidisciplinary management of their most challenging cases. While most cases presented were confirmed IBD, a substantial number were diseases that mimic IBD. We have categorized all IBD LIVE cases and identified "IBD-mimics" with consequent clinical management implications.
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