Publications by authors named "J R Ostergaard"
Article Synopsis
- Neurofibromatosis type 1 (NF1) is a genetic disorder that can cause various health issues, including cognitive impairments, which are not well-studied in adults; this research focused on evaluating these cognitive issues in adults with NF1.* -
- The study involved 103 NF1 adults and 38 control participants, utilizing a range of neurocognitive tests and a self-report questionnaire to analyze various cognitive functions including intelligence, memory, attention, and executive functions.* -
- Results revealed that adults with NF1 experience significant impairments, particularly in areas like intelligence and visual memory, while some cognitive functions remained intact, suggesting a specific pattern of cognitive deficits rather than a widespread impairment.*
Article Synopsis
- This study investigates how different ratios of excipients like lactose, microcrystalline cellulose, and dicalcium phosphate affect the swelling and drug release of propranolol hydrochloride (PPN) from polyethylene oxide (PEO) matrix compacts.
- The researchers used microscopy to analyze the compact surfaces and conducted dissolution studies to assess how the excipient ratios influenced hydration rates and drug release dynamics.
- Findings indicate that modifying the amount of PEO and the type or ratio of excipients can significantly affect drug release rates, highlighting the innovative use of UV dissolution imaging for optimizing formulations.
Article Synopsis
- The study investigates autonomic activity in adolescents with Juvenile Ceroid Lipofuscinosis (CLN3-disease) experiencing recurrent non-epileptic episodes resembling paroxysmal sympathetic hyperactivity (PSH).
- Researchers monitored heart rate variability (HRV) over a week and focused on HRV parameters before, during, and after PSH-like episodes in seven Danish patients aged 15 and older.
- Results indicated a significant drop in parasympathetic activity just before PSH-like episodes and maintained low levels during and shortly after the episodes, while sympathetic activity remained unchanged, suggesting sympathetic overactivity during these events.
Introduction: Several evaluations of lifestyle interventions for childhood obesity exist; however, follow-up beyond 2 years is necessary to validate the effect. The aim of the present study was to investigate long-term weight development following children participating in one of two pragmatic family-centered lifestyle interventions treating childhood obesity.
Methods: This real-life observational study included Danish children 4-17 years of age classified as having obesity.
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, with relapse being a major obstacle to successful treatment. Our understanding of the mechanisms driving chemotherapy resistance and ultimately relapse in leukemia remains incomplete. Herein, we investigate the impact of the tumor microenvironment on leukemia cell drug responses using human plasma-like media (HPLM), designed to mimic physiological conditions more accurately .
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