Publications by authors named "J R Myles"
Article Synopsis
- - Digital breast tomosynthesis (DBT), when used with a synthetic 2D mammogram (S2D), exposes women to higher radiation but may enhance cancer detection compared to full-field digital mammography (FFDM) alone.
- - A review of 17 studies, including 13 for meta-analysis, found that DBT plus S2D provided a higher cancer detection rate compared to FFDM alone, while also showing similar accuracy to DBT with FFDM.
- - The findings suggest that integrating S2D with DBT in breast cancer screening is effective and maintains the safety and performance of the imaging process.
Parallelized Immunomagnetic Isolation of Basophils Directly from Whole Blood.
Adv Nanobiomed Res
February 2024
Basophils are the rarest circulating white blood cells (WBCs), but they play important roles in allergic disorders and other diseases. To enhance diagnostic capabilities, it would be desirable to isolate and analyze basophils efficiently from small blood samples. In 100 μL of whole blood, there are typically ~10 basophils, outnumbered by ~10 WBCs and ~10 red blood cells (RBCs).
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- Pathologic re-review of TURBT specimens at a tertiary care center was evaluated to understand its impact on disease risk stratification for bladder cancer patients.
- Out of 173 patients whose specimens were re-reviewed, changes in grade, clinical stage, and risk stratification were observed, particularly in those with less advanced (
- The study found that re-review by a GU pathologist affected more than 20% of patients' risk assessments, highlighting its importance in potentially altering patient management strategies.
Article Synopsis
- GM1 gangliosidosis (GM1) is a lysosomal disorder caused by mutations in the GLB1 gene, leading to serious neurodegeneration and currently has no approved treatments.
- A study involving 41 patients with type II GM1 revealed distinct genetic variants and observed that many children had normal hearing and did not exhibit typical symptoms seen in type I GM1.
- The research highlighted progressive brain atrophy and identified crucial correlations between brain chemistry changes and patient behavior scores, emphasizing the importance of this long-term study for improving diagnosis and developing future therapies.
Article Synopsis
- GM1 gangliosidosis is a rare genetic disease mainly affecting children, characterized by neurodegeneration, and currently has no approved treatments but is under investigation through gene therapy and other trials.
- A study involving 41 individuals with type II GM1 assessed various health factors, revealing unique characteristics and differences compared to type I infantile forms, such as normal hearing and specific heart issues in older children.
- The study provided new insights into the disease's progression and aimed to correct misunderstandings about type II GM1, enhancing the knowledge base for future diagnosis and treatment approaches.