Rapid and scalable personalized ASO screening in patient-derived organoids.

Personalized antisense oligonucleotides (ASOs) have achieved positive results in the treatment of rare genetic disease. As clinical sequencing technologies continue to advance, the ability to identify patients with rare disease harbouring pathogenic genetic variants amenable to this therapeutic strategy will probably improve. Here we describe a scalable platform for generating patient-derived cellular models and demonstrate that these personalized models can be used for preclinical evaluation of patient-specific ASOs.

Neonatal Seizures and Associated Neurobehavioral Profiles in Preschool Age Children.

Background: Neonatal seizures are common with acute brain injury. Up to 25% of survivors develop postneonatal epilepsy. We hypothesized postneonatal epilepsy diagnosed by age 24 months would increase risk for early markers of neurobehavioral disorders than acute provoked neonatal seizures alone.

Cayenniola albaserrata n. sp., a geographical relict from a Brazilian hotspot of subterranean biodiversity and the first troglobitic Priodesmini (Polydesmida: Chelodesmidae: Chelodesminae).

A new troglobitic species of Chelodesmidae, Cayenniola albaserrata n. sp., from the Água Clara cave system, Caatinga Domain, Bahia, Brazil is described.

A bibliographic review of the Chelodesmidae of the Antilles and Bahamas (Diplopoda: Polydesmida).

Among millipede groups found in the Antilles, the family Chelodesmidae is the most species diverse and well represented in collections. However, to date, there has not been a bibliographic review of the family for the region. Here we compile and review the literature for the Chelodesmidae of the Antilles and the Bahamas, clarify the family's status for the region, and discuss the central deficits of its taxonomy and the most relevant obstacles for work in the group.