Publications by authors named "J R Martens"
One of the main challenges in oligosaccharide synthesis is the stereoselective introduction of the glycosidic bond. In order to understand and control glycosylation reactions, thorough mechanistic studies are required. Reaction intermediates found by NMR spectroscopy often cannot explain the glycosylation's stereochemical outcome.
View Article and Find Full Text PDFImportance: Efficient care processes are crucial to minimize treatment delays and improve outcome after endovascular thrombectomy (EVT) in patients with ischemic stroke. A potential means to improve care processes is performance feedback.
Objective: To evaluate the effect of performance feedback to hospitals on treatment times for EVT.
KMT2A::MLLT3 acute myelomonocytic leukemia (AML) comes in two clinically and biologically different subtypes. One is characterized by inferior outcome, older age, and MECOM oncogene expression. The other is mainly observed in children and young adults, associates with better clinical outcome, but lacks MECOM.
View Article and Find Full Text PDFArticle Synopsis
- - Glutathione (GSH) is an important tripeptide that protects cells from oxidative stress and removes toxic heavy metals, with the study focusing on its coordination with metals essential for biological redox processes: Zn, Cu, and Fe.
- - Using infrared multiple photon dissociation (IRMPD) spectroscopy, researchers identified complexes formed between these metals and deprotonated GSH, revealing significant differences in metal coordination preferences based on experimental and theoretical vibrational spectra.
- - The findings highlight common spectral features among the metal complexes while also indicating that the cysteine component of glutathione plays a crucial role in coordinating with these metals, which is relevant for understanding their biochemical functions.