Publications by authors named "J R Marquis"
Endosomal nucleic acid sensing by Toll-like receptors (TLRs) is central to antimicrobial immunity and several autoimmune conditions such as systemic lupus erythematosus (SLE). The innate immune adaptor TASL mediates, via the interaction with SLC15A4, the activation of IRF5 downstream of human TLR7, TLR8 and TLR9, but the pathophysiological functions of this axis remain unexplored. Here we show that SLC15A4 deficiency results in a selective block of TLR7/9-induced IRF5 activation, while loss of TASL leads to a strong but incomplete impairment, which depends on the cell type and TLR engaged.
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- The study analyzes the properties of convective cells and their effects on different types of rainfall during a 3.5-month evaluation period in central Argentina, using data from the RELAMPAGO-CACTI field campaign.
- The simulation shows a significant discrepancy in rainfall predictions, particularly underestimating stratiform rainfall by 46% and overestimating convective rainfall by 43%, linked to an excessive number of generated precipitating convective cells.
- Despite attempts to enhance simulation accuracy by changing model resolution, the results indicate that simply increasing resolution is not enough; other factors also play a crucial role in improving predictions of convective properties.
The cell cycle-regulated DNA methyltransferase CcrM is conserved in most Alphaproteobacteria, but its role in bacteria with complex or multicentric genomes remains unexplored. Here, we compare the methylome, the transcriptome and the phenotypes of wild-type and CcrM-depleted Agrobacterium tumefaciens cells with a dicentric chromosome with two essential replication origins. We find that DNA methylation has a pleiotropic impact on motility, biofilm formation and viability.
View Article and Find Full Text PDFOur recent randomized, placebo-controlled study in Irritable Bowel Syndrome (IBS) patients with diarrhea or alternating bowel habits showed that the probiotic (BL) NCC3001 improves depression scores and decreases brain emotional reactivity. However, the involved metabolic pathways remain unclear. This analysis aimed to investigate the biochemical pathways underlying the beneficial effects of BL NCC3001 using metabolomic profiling.
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- - Neutrophils play a crucial role in fighting infections, but their function in drug-resistant infections, like leishmaniasis, is not well understood.
- - Research shows that drug-resistant parasites change the expression of certain neutrophil genes, increasing detoxification processes and reducing cytokine production, particularly impacting a chemokine called CCL3.
- - Reduced CCL3 levels hinder neutrophils’ ability to recruit other immune cells, which was confirmed in mouse models, highlighting how drug-resistant parasites can alter immune responses in infected skin.