Publications by authors named "J R Marcus"
Article Synopsis
- Doxycycline postexposure prophylaxis (doxyPEP) effectively reduces the incidence of bacterial sexually transmitted infections (STIs) in those assigned male at birth, although practical data is limited.
- This study analyzed electronic health records of HIV PrEP users from Kaiser Permanente Northern California to assess the uptake of doxyPEP and its impact on STI rates before and after its initiation.
- Out of 11,551 HIV PrEP users, 19.5% received doxyPEP, with a notable percentage having an STI prior; findings suggest changes in STI positivity rates among those who started doxyPEP versus those who did not.
Article Synopsis
- Lysosomal storage disorders (LSDs) and Alzheimer's disease (AD) show overlapping features, particularly with lysosomal dysfunction potentially playing a role in AD pathogenesis.
- Research found that lysosomal ionic regulation is disrupted in blood-derived monocytes from AD patients, which correlates with known AD pathology markers.
- A machine learning model developed from this data suggests a promising noninvasive biomarker platform for diagnosing AD and emphasizes the need to explore therapies aimed at restoring lysosome function.
Introduction: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on physical fitness in previously healthy adults is not well understood. In this study, we assess the impact of SARS-CoV-2 infection on the physical fitness test (PT) scores of Air Force basic trainees.
Materials And Methods: SARS-CoV-2 testing data and trainee fitness test scores for the calendar year 2021 were obtained from U.
The conventional gradient-echo steady-state signal model is the basis of various spoiled gradient-echo (SPGR) based quantitative MRI models, including variable flip angle (VFA) MRI and dynamic contrast-enhanced MRI (DCE). However, including preparation pulses, such as fat suppression or saturation bands, disrupts the steady-state and leads to a bias in T and DCE parameter estimates. This work introduces a signal model that improves the accuracy of VFA T-mapping and DCE for interrupted spoiled gradient-echo (I-SPGR) acquisitions.
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