Publications by authors named "J R M Jepsen"
Background And Purpose: The heterogeneous outcomes used in lower-limb lengthening surgery (LLLS) complicate evidence synthesis, weakening systematic reviews and clinical recommendations, and reducing research impact. This scoping review maps the outcomes and outcome measurement instruments (OMIs) used in LLLS.
Methods: This pre-registered review systematically identified studies reporting outcomes in adults or children who underwent LLLS.
Article Synopsis
- Neurofibromatosis type 1 (NF1) is a genetic disorder that can cause various health issues, including cognitive impairments, which are not well-studied in adults; this research focused on evaluating these cognitive issues in adults with NF1.* -
- The study involved 103 NF1 adults and 38 control participants, utilizing a range of neurocognitive tests and a self-report questionnaire to analyze various cognitive functions including intelligence, memory, attention, and executive functions.* -
- Results revealed that adults with NF1 experience significant impairments, particularly in areas like intelligence and visual memory, while some cognitive functions remained intact, suggesting a specific pattern of cognitive deficits rather than a widespread impairment.*
Needle-based injections currently enable the administration of a wide range of biomacromolecule therapies across the body, including the gastrointestinal tract, through recent developments in ingestible robotic devices. However, needles generally require training, sharps management and disposal, and pose challenges for autonomous ingestible systems. Here, inspired by the jetting systems of cephalopods, we have developed and evaluated microjet delivery systems that can deliver jets in axial and radial directions into tissue, making them suitable for tubular and globular segments of the gastrointestinal tract.
View Article and Find Full Text PDFBackground: It is known that impairments in linguistic ability and motor function tend to co-occur in children, and that children from families with parental mental illness such as schizophrenia tend to perform poorly in both domains, but the exact nature of these links has not yet been fully elucidated.
Design: In this study, we leveraged the first wave of the Danish High Risk and Resilience Study (VIA 7), which includes both genetic data and measures covering multiple developmental domains. The VIA 7 cohort comprises 522 7-year-old children born to parents with schizophrenia (N = 202), bipolar disorder (N = 120) or neither (N = 200).
Background: Children of parents with a severe mental illness have an increased risk of developing a lifetime mental illness. We aimed to compare the effects of a preventive family-based intervention, VIA Family, with treatment as usual (TAU) on these children's global functioning.
Methods: Between 2017 and 2021, we conducted a pragmatic, rater-blinded, two-arm parallel-group superiority trial in Denmark.