Rabies immune globulin of human origin: preparation and dosage determination in non-exposed volunteer subjects.

A clinical study was carried out in volunteer subjects to determine the proper dosage of rabies immune globulin (human) (RIGH) when used in conjunction with rabies vaccine of duck-embryo origin (DEV). Two lots of RIGH were prepared from plasma pools derived from donors with high titres of rabies-neutralizing antibody; both lots had potencies in excess of that accepted for antirabies serum of equine origin. The subjects had never received rabies vaccine but would oridinarily have been given pre-exposure rabies prophylaxis.